Retinoic acid receptor alpha gene variants, multivitamin use, and liver intake as risk factors for oral clefts: A population-based case-control study in Denmark, 1991-1994

Laura E MITCHELL; Jeffrey C MURRAY; Sarah O'BRIEN; Kaare CHRISTENSEN

doi:10.1093/aje/kwg102

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Retinoic acid receptor alpha gene variants, multivitamin use, and liver intake as risk factors for oral clefts: A population-based case-control study in Denmark, 1991-1994

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Retinoic acid receptor alpha gene variants, multivitamin use, and liver intake as risk factors for oral clefts: A population-based case-control study in Denmark, 1991-1994

Laura E MITCHELL, Jeffrey C MURRAY, Sarah O'BRIEN and Kaare CHRISTENSEN

American journal of epidemiology, Vol.158(1), pp.69-76

2003

DOI: 10.1093/aje/kwg102

PMID: 12835288

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Abstract

Previous studies suggest that the risks of nonsyndromic cleft lip with or without cleft palate (CL+/-P) and isolated cleft palate are influenced by variation at several loci and that these loci interact with environmental factors to determine disease risk. One putative genetic risk factor for these conditions is the retinoic acid receptor alpha (RARA) locus, which is involved in cell-specific responses to retinoic acid. Hence, RARA may influence disease risk via an interaction with vitamin A and related compounds. Data from a Danish case-control study (1991-1994) were used to evaluate the relations between oral clefts, RARA, and maternal vitamin A exposure from multivitamins and liver. Analyses provided no compelling evidence that the risks of CL+/-P or isolated cleft palate are related to the RARA variant analyzed. Consistent with several previous studies, the authors' analyses indicated that maternal multivitamin supplement use protects against CL+/-P. Within the range observed in this population, higher levels of vitamin A intake from multivitamins and liver sources also seemed to protect against CL+/-P. Exploratory analyses suggested that the latter association was not entirely explained by the association between CL+/-P and multivitamin use, indicating that adequate levels of vitamin A may be required for normal development of the primary palate.

Biological and medical sciences

Medical sciences

Facial bones, jaws, teeth, parodontium: diseases, semeiology

Otorhinolaryngology. Stomatology

Non tumoral diseases

Details

Title: Subtitle: Retinoic acid receptor alpha gene variants, multivitamin use, and liver intake as risk factors for oral clefts: A population-based case-control study in Denmark, 1991-1994
Creators: Laura E MITCHELL - Department of Biomedical Sciences, Baylor College of Dentistry, The Texas A&M University System Health Science Center, Houston, TX, United States
Jeffrey C MURRAY - Department of Pediatrics, University of Iowa, Iowa City, IA, United States
Sarah O'BRIEN - Department of Pediatrics, University of Iowa, Iowa City, IA, United States
Kaare CHRISTENSEN - Center for Prevention of Congenital Malformations, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.158(1), pp.69-76
DOI: 10.1093/aje/kwg102
PMID: 12835288
NLM abbreviation: Am J Epidemiol
ISSN: 0002-9262
eISSN: 1476-6256
Publisher: Oxford University Press; Cary, NC
Language: English
Date published: 2003
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025668802771

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