Journal article
Retinoids and pulmonary alveolar regeneration: Rationale and therapeutic challenges
Drug discovery today. Disease mechanisms, Vol.3(1), pp.77-84
2006
DOI: 10.1016/j.ddmec.2006.03.005
Abstract
Retinoids, whose parent compound retinol (Vitamin A) regulates airway branching and epithelial maturation, are required for normal alveolar development. Retinoic acid (RA) isomers can also enhance the restoration of alveoli after injury of the lung in newborns (bronchopulmonary dysplasia) or in adults (emphysema). RA promotes alveolar type 2 cell maturation and surfactant protein production, regulates endothelial proliferation and vascular maturation, and increases elastin and collagen synthesis by interstitial fibroblasts. Although the restorative mechanisms in individual cell-types are being defined, understanding how these mechanisms are coordinated to regenerate structurally and functionally normal alveoli, remains a major challenge.
Maria Belvisi – Imperial College School of Medicine, London, UK
Stuart Farrow – GlaxoSmithKline, Stevenage, UK
Details
- Title: Subtitle
- Retinoids and pulmonary alveolar regeneration: Rationale and therapeutic challenges
- Creators
- Stephen E. McGowan - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Drug discovery today. Disease mechanisms, Vol.3(1), pp.77-84
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.ddmec.2006.03.005
- ISSN
- 1740-6765
- eISSN
- 1740-6765
- Language
- English
- Date published
- 2006
- Academic Unit
- International Programs; Internal Medicine; Pulmonary, Critical Care, and Occupational Medicine
- Record Identifier
- 9984359877802771
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