Retinol-binding protein in idiopathic intracranial hypertension (IIH)

John B SELHORST; Kongkiat KULKANTRAKORN; James J CORBETT; Enrique C LEIRA; Sophia M CHUNG

doi:10.1097/00041327-200020040-00009

Back

Retinol-binding protein in idiopathic intracranial hypertension (IIH)

Journal article

Peer reviewed

Retinol-binding protein in idiopathic intracranial hypertension (IIH)

John B SELHORST, Kongkiat KULKANTRAKORN, James J CORBETT, Enrique C LEIRA and Sophia M CHUNG

Journal of neuro-ophthalmology, Vol.20(4), pp.250-252

2000

DOI: 10.1097/00041327-200020040-00009

PMID: 11130751

View Online

Abstract

Objective: We postulated that an alteration in endogenous vitamin A (retinol) metabolism plays a causal role in the pathogenesis of idiopathic intracranial hypertension (IIH). Materials and Methods: Serum retinol was determined by a fluorometric method from 40 control subjects and 58 patients with idiopathic intracranial hypertension (IIH). Retinol binding protein (RBP) was also assayed by quantitative radial immunodiffusion in 17 control subjects and 30 patients with IIH. Results: Mean retinol values were higher in the IIH group compared with the control group, but did not reach a significant level. However, seven of 30 patients with IIH had high RBP levels, but none of the control subjects did. Conclusion: This data suggests that IIH is associated with an abnormality in vitamin A metabolism that is linked to its transport system.

Neurology

Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy

Biological and medical sciences

Medical sciences

Nervous system (semeiology, syndromes)

Details

Title: Subtitle: Retinol-binding protein in idiopathic intracranial hypertension (IIH)
Creators: John B SELHORST - Departments of Neurology and Ophthalmology, Saint Louis University School of Medicine, St. Louis, Missouri, United States
Kongkiat KULKANTRAKORN - Departments of Neurology and Ophthalmology, Saint Louis University School of Medicine, St. Louis, Missouri, United States
James J CORBETT - Departments of Neurology and Ophthalmology, Saint Louis University School of Medicine, St. Louis, Missouri, United States
Enrique C LEIRA - Departments of Neurology and Ophthalmology, Saint Louis University School of Medicine, St. Louis, Missouri, United States
Sophia M CHUNG - Departments of Neurology and Ophthalmology, Saint Louis University School of Medicine, St. Louis, Missouri, United States
Resource Type: Journal article
Publication Details: Journal of neuro-ophthalmology, Vol.20(4), pp.250-252
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
DOI: 10.1097/00041327-200020040-00009
PMID: 11130751
ISSN: 1070-8022
eISSN: 1536-5166
Language: English
Date published: 2000
Academic Unit: Neurology; Epidemiology; Iowa Neuroscience Institute; Neurosurgery; Ophthalmology and Visual Sciences
Record Identifier: 9984020717302771

Metrics

12 Record Views

26 Times Cited - Web of Science