Journal article
Retinol, supplemental vitamin A and bone status
Journal of clinical epidemiology, Vol.43(7), pp.693-699
1990
DOI: 10.1016/0895-4356(90)90040-V
PMID: 2370577
Abstract
Studies of hypervitaminosis A in animals and anecdotal reports of accidental vitamin A poisoning in humans suggest impairment of bone remodeling and increased numbers of fractures. Because of the widespread use of high-dose vitamin A supplements which may produce subclinical hypervitaminosis associated with decreased bone mass and increased risk of fracture, we studied the relationship between current vitamin A supplement use, serum retinol levels, radial bone mass and fracture history in a geographically-defined population of 246 postmenopausal women, 55–80 years of age. More than 36% of this population used a vitamin A supplement with 8% of these consuming an amount in excess of 2000 retinol equivalents (RE)/day. Serum retinol was measured using high-pressure liquid chromatography and radial bone mass was measured using single photon absorptiometry. After controlling for age, current estrogen replacement, and current thiazide antihypertensive use, we observed no statistically significant relationship between vitamin A supplement use or serum retinol with radial bone mass or fractures.
Details
- Title: Subtitle
- Retinol, supplemental vitamin A and bone status
- Creators
- Maryfran R. Sowers - University of MichiganRobert B. Wallace - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of clinical epidemiology, Vol.43(7), pp.693-699
- DOI
- 10.1016/0895-4356(90)90040-V
- PMID
- 2370577
- NLM abbreviation
- J Clin Epidemiol
- ISSN
- 0895-4356
- eISSN
- 1878-5921
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1990
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363572802771
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