Journal article
Retraction notice: L-Type Ca2+ Channel Facilitation Mediated by Phosphorylation of the beta Subunit by CaMKII (Retraction of vol 23, pg 641, 2006)
Molecular cell, Vol.58(2), pp.388-388
04/16/2015
DOI: 10.1016/j.molcel.2015.04.007
PMID: 26065042
Abstract
This article has been retracted at the request of the authors. The NIH Office of Research Integrity (ORI) has investigated the third author of this paper, Igor Dzhura. Following the investigation, the ORI reported that Dzhura “engaged in research misconduct by submitting and publishing multiple falsified and/or fabricated action potential traces” in research he conducted in multiple laboratories (published November 2014; https://ori.hhs.gov/content/case-summary-dzhura-igor).
Dzhura’s sole contribution to this paper was the data reported in Figure 3, showing single-channel activities of CaV1.2 L-type calcium channels under various conditions. Inspection of Figure 3 revealed inappropriate duplications of exemplar current traces. While subsequent published studies have supported the central findings of this paper, including data showing that CaMKII facilitates CaV1.2 channels in cardiomyocytes by binding to and phosphorylating Thr498 in the β2a subunit (Koval et al. [2010], Proc. Natl. Acad. Sci. USA 107, 4996–5000), the authors are retracting the paper because it contains falsified data. The authors apologize to the scientific community for any inconveniences or challenges resulting from the publication and retraction of this manuscript.
Details
- Title: Subtitle
- Retraction notice: L-Type Ca2+ Channel Facilitation Mediated by Phosphorylation of the beta Subunit by CaMKII (Retraction of vol 23, pg 641, 2006)
- Creators
- Chad E. GrueterSunday A. AbiriaIgor DzhuraYuejin WuAmy-Joan L. HamPeter J. MohlerMark E. AndersonRoger J. Colbran
- Resource Type
- Journal article
- Publication Details
- Molecular cell, Vol.58(2), pp.388-388
- DOI
- 10.1016/j.molcel.2015.04.007
- PMID
- 26065042
- NLM abbreviation
- Mol Cell
- ISSN
- 1097-2765
- eISSN
- 1097-4164
- Publisher
- Elsevier
- Number of pages
- 1
- Comment
- Retraction of: L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII. Grueter CE, Abiria SA, Dzhura I, Wu Y, Ham AJ, Mohler PJ, Anderson ME, Colbran RJ. Mol Cell. 2006 Sep 1;23(5):641-50. doi: 10.1016/j.molcel.2006.07.006. PMID: 16949361
- Language
- English
- Date published
- 04/16/2015
- Academic Unit
- Cardiovascular Medicine; Craniofacial Anomalies Research Center; Internal Medicine
- Record Identifier
- 9984359594202771
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