Retrospective analysis of the diagnostic yield of newborn drug testing

Kelly E. Wood; Lori L. Sinclair; Carolyn D. Rysgaard; Frederick G. Strathmann; Gwendolyn A. McMillin; Matthew D. Krasowski

doi:10.1186/1471-2393-14-250

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Retrospective analysis of the diagnostic yield of newborn drug testing

Journal article

Open access

Peer reviewed

Retrospective analysis of the diagnostic yield of newborn drug testing

Kelly E. Wood, Lori L. Sinclair, Carolyn D. Rysgaard, Frederick G. Strathmann, Gwendolyn A. McMillin and Matthew D. Krasowski

BMC Pregnancy and Childbirth, Vol.14, 250 (2014)

01/01/2014

DOI: 10.1186/1471-2393-14-250

PMCID: PMC4124162

PMID: 25073780

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Published (Version of record)BMC Pregnancy Childbirth. 2014; 14: 250.

Abstract

Background The objective of this study was to identify high-yield screening risk factors for detecting maternal non-medical drug use during pregnancy. Methods A four year retrospective analysis was conducted at an academic medical center. Detailed chart review of both the newborn and mother’s medical record was performed on all cases for which one or more drug(s) or metabolite(s) were identified and confirmed in meconium or urine. Results 229 (9.2%) of 2,497 meconium samples out of 7,749 live births confirmed positive for one or more non-medical drugs. History of maternal non-medical drug and/or tobacco use in pregnancy was present in 90.8% of non-medical drug use cases. Addition of social risk factors and inadequate prenatal care increased the yield to 96.9%. Conclusions Use of focused screening criteria based on specific maternal and social risk factors may detect many prenatal non-medical drug exposures.

Cocaine

Pediatrics

Pregnancy

Prenatal Care

Tobacco

OAfund

Meconium drug abuse detection/testing

maternal tobacco use

social risk factors

newborn screening

Urine drug abuse detection/testing

Non-medical drug use

Fetal drug exposure

Prenatal drug abuse

Substance abuse testing

benzodiazepines

opioids

amphetamines

dronabinol

mothers

babies

newborns

drugs

drug tests

Details

Title: Subtitle: Retrospective analysis of the diagnostic yield of newborn drug testing
Creators: Kelly E. Wood - University of Iowa
Lori L. Sinclair - University of Iowa
Carolyn D. Rysgaard - University of Iowa
Frederick G. Strathmann
Gwendolyn A. McMillin
Matthew D. Krasowski - University of Iowa
Resource Type: Journal article
Publication Details: BMC Pregnancy and Childbirth, Vol.14, 250 (2014)
DOI: 10.1186/1471-2393-14-250
PMID: 25073780
PMCID: PMC4124162
NLM abbreviation: BMC Pregnancy Childbirth
ISSN: 1471-2393
Language: English
Date published: 01/01/2014
Academic Unit: Stead Family Department of Pediatrics; Pathology; Carver College of Medicine; Hospital Medicine
Record Identifier: 9983557355502771

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