Journal article
Retrospective respiratory self‐gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults
Magnetic resonance in medicine, Vol.77(3), pp.1284-1295
03/2017
DOI: 10.1002/mrm.26212
PMCID: PMC5018908
PMID: 26972576
Abstract
Purpose
To implement pulmonary three‐dimensional (3D) radial ultrashort echo‐time (UTE) MRI in non‐sedated, free‐breathing neonates and adults with retrospective motion tracking of respiratory and intermittent bulk motion, to obtain diagnostic‐quality, respiratory‐gated images.
Methods
Pulmonary 3D radial UTE MRI was performed at 1.5 tesla (T) during free breathing in neonates and adult volunteers for validation. Motion‐tracking waveforms were obtained from the time course of each free induction decay's initial point (i.e., k‐space center), allowing for respiratory‐gated image reconstructions that excluded data acquired during bulk motion. Tidal volumes were calculated from end‐expiration and end‐inspiration images. Respiratory rates were calculated from the Fourier transform of the motion‐tracking waveform during quiet breathing, with comparison to physiologic prediction in neonates and validation with spirometry in adults.
Results
High‐quality respiratory‐gated anatomic images were obtained at inspiration and expiration, with less respiratory blurring at the expense of signal‐to‐noise for narrower gating windows. Inspiration‐expiration volume differences agreed with physiologic predictions (neonates; Bland‐Altman bias = 6.2 mL) and spirometric values (adults; bias = 0.11 L). MRI‐measured respiratory rates compared well with the observed rates (biases = −0.5 and 0.2 breaths/min for neonates and adults, respectively).
Conclusions
Three‐dimensional radial pulmonary UTE MRI allows for retrospective respiratory self‐gating and removal of intermittent bulk motion in free‐breathing, non‐sedated neonates and adults. Magn Reson Med 77:1284–1295, 2017. © 2016 International Society for Magnetic Resonance in Medicine
Details
- Title: Subtitle
- Retrospective respiratory self‐gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults
- Creators
- Nara S. Higano - Cincinnati Children's Hospital Medical CenterAndrew D. Hahn - University of Wisconsin–MadisonJean A. Tkach - Cincinnati Children's Hospital Medical CenterXuefeng Cao - Cincinnati Children's Hospital Medical CenterLaura L. Walkup - Cincinnati Children's Hospital Medical CenterRobert P. Thomen - Cincinnati Children's Hospital Medical CenterStephanie L. Merhar - Cincinnati Children's Hospital Medical CenterPaul S. Kingma - Cincinnati Children's Hospital Medical CenterSean B. Fain - University of Wisconsin–MadisonJason C. Woods - Cincinnati Children's Hospital Medical Center
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.77(3), pp.1284-1295
- DOI
- 10.1002/mrm.26212
- PMID
- 26972576
- PMCID
- PMC5018908
- NLM abbreviation
- Magn Reson Med
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Number of pages
- 12
- Grant note
- Perinatal Institute at CCHMC (NIH P01 HL070831 ; NIH T32 HL007752 ; NIH T32 CA009206)
- Language
- English
- Date published
- 03/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984275054602771
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