Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients

Erin Jou; Oleg Gligich; Alvita C Y Chan; Diwakar Mohan; Uriel R Felsen; Sabarish Ayyappan; Henny H Billett; Edwin P Hui; Anthony T Chan; Radha Raghupathy

doi:10.1002/hon.2247

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Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients

Journal article

Open access

Peer reviewed

Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients

Erin Jou, Oleg Gligich, Alvita C Y Chan, Diwakar Mohan, Uriel R Felsen, Sabarish Ayyappan, Henny H Billett, Edwin P Hui, Anthony T Chan and Radha Raghupathy

Hematological oncology, Vol.35(1), pp.64-68

03/2017

DOI: 10.1002/hon.2247

PMID: 26205037

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Abstract

The significance of HIV associated paraproteins and their risk of progression to hematological malignancies remains unclear. We compared the development of hematological malignancies among HIV+ (n = 266) and HIV- (n = 537) patients with monoclonal gammopathies. HIV+ and HIV- patients with a positive serum protein electrophoresis test (SPEP) were studied. HIV+ SPEP+ were more likely to have faint and oligoclonal paraproteins (F-SPEP) and less likely to have discrete bands (D-SPEP) compared to HIV- SPEP+. The incidence of hematological malignancies was significantly lower in the HIV+ compared to the HIV- (6.4% vs 15.4%, p < 0.0002). Upon subgroup analysis, the lower incidence of hematological malignancies was noted for HIV+ patients with F-SPEP but not for those with D-SPEP. Copyright © 2015 John Wiley & Sons, Ltd.

Algorithms

Cell Proliferation

Disease Progression

Female

Hematologic Neoplasms - complications

Hematologic Neoplasms - immunology

HIV Infections - complications

HIV Infections - epidemiology

HIV Infections - immunology

Humans

Incidence

Male

Middle Aged

Models, Statistical

Monoclonal Gammopathy of Undetermined Significance - complications

Monoclonal Gammopathy of Undetermined Significance - epidemiology

Monoclonal Gammopathy of Undetermined Significance - immunology

Odds Ratio

Prevalence

Regression Analysis

Retrospective Studies

Risk

Treatment Outcome

Details

Title: Subtitle: Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients
Creators: Erin Jou - Albert Einstein College of Medicine
Oleg Gligich - Albert Einstein College of Medicine
Alvita C Y Chan - Chinese University of Hong Kong
Diwakar Mohan - Johns Hopkins University
Uriel R Felsen - Albert Einstein College of Medicine
Sabarish Ayyappan - University Hospitals Cleveland Medical Center
Henny H Billett - Albert Einstein College of Medicine
Edwin P Hui - Chinese University of Hong Kong
Anthony T Chan - Partner State Key Laboratory of Oncology in South China, Sir Y K Pao Centre for Cancer, Department of Clinical Oncology, Hong Kong Cancer Institute and Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
Radha Raghupathy - Chinese University of Hong Kong
Resource Type: Journal article
Publication Details: Hematological oncology, Vol.35(1), pp.64-68
DOI: 10.1002/hon.2247
PMID: 26205037
NLM abbreviation: Hematol Oncol
ISSN: 0278-0232
eISSN: 1099-1069
Grant note: name: Einstein Montefiore Center for AIDS Research, award: NIH AI-051519
Language: English
Date published: 03/2017
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984359806302771

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