Journal article
Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein
Current opinion in hematology, Vol.8(4), pp.218-223
07/2001
DOI: 10.1097/00062752-200107000-00007
PMID: 11561159
Abstract
The in-frame fusion of mixed lineage leukemia to CREB binding protein has been cloned from several patients with t-acute myeloid leukemia and a t(11;16)(q23;p13). A murine retroviral transduction model of mixed lineage leukemia fused to CREB binding protein successfully recapitulates the disease. Interestingly, the mice also develop a preleukemic phase reminiscent of what is often seen in patients with t(11;16). From this work, it was determined that minimally, the amino terminus of mixed lineage leukemia fused to the bromodomain and histone acetyltransferase domain of CREB binding protein are necessary for developing acute myeloid leukemia. This model provides a useful tool for understanding the biologic basis of mixed lineage leukemia leukemogenesis and for developing and testing potential therapeutic agents.
Details
- Title: Subtitle
- Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein
- Creators
- Donna Liedman - Loyola University Medical CenterNancy Zeleznik-Le
- Resource Type
- Journal article
- Publication Details
- Current opinion in hematology, Vol.8(4), pp.218-223
- Publisher
- Lippincott Williams & Wilkins, Inc
- DOI
- 10.1097/00062752-200107000-00007
- PMID
- 11561159
- ISSN
- 1065-6251
- eISSN
- 1531-7048
- Language
- English
- Date published
- 07/2001
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984318327102771
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