Journal article
Revealing the Hippocampal Connectome through Super-Resolution 1150-Direction Diffusion MRI
Scientific reports, Vol.9(1), p.2418
02/20/2019
DOI: 10.1038/s41598-018-37905-9
PMCID: PMC6382767
PMID: 30787303
Abstract
The hippocampus is a key component of emotional and memory circuits and is broadly connected throughout the brain. We tracked the whole-brain connections of white matter fibres from the hippocampus using ultra-high angular resolution diffusion MRI in both a single 1150-direction dataset and a large normal cohort (n = 94; 391-directions). Using a connectomic approach, we identified six dominant pathways in terms of strength, length and anatomy, and characterised them by their age and gender variation. The strongest individual connection was to the ipsilateral thalamus. There was a strong age dependence of hippocampal connectivity to medial occipital regions. Overall, our results concur with preclinical and ex-vivo data, confirming that meaningful in vivo characterisation of hippocampal connections is possible in an individual. Our findings extend the collective knowledge of hippocampal anatomy, highlighting the importance of the spinal-limbic pathway and the striking lack of hippocampal connectivity with motor and sensory cortices.
Details
- Title: Subtitle
- Revealing the Hippocampal Connectome through Super-Resolution 1150-Direction Diffusion MRI
- Creators
- Jerome J. Maller - The Heart Research InstituteThomas Welton - The University of SydneyMatthew Middione - Applied Sciences LaboratoryFraser M. Callaghan - The Heart Research InstituteJeffrey Rosenfeld - Monash UniversityStuart M. Grieve - The Heart Research Institute
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.9(1), p.2418
- DOI
- 10.1038/s41598-018-37905-9
- PMID
- 30787303
- PMCID
- PMC6382767
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- NATURE PORTFOLIO
- Number of pages
- 13
- Grant note
- Parker-Hughes Bequest Heart Research Institute; University of Sydney Sydney Medical School
- Language
- English
- Date published
- 02/20/2019
- Academic Unit
- Radiology
- Record Identifier
- 9984848505802771
Metrics
4 Record Views