Journal article
Reversal of anticoagulation with four-factor prothrombin complex concentrate without concurrent vitamin K (phytonadione) for urgent surgery in a patient at moderate-to-high risk for thromboembolism
BMJ case reports, Vol.2016, p.bcr2016217092
10/27/2016
DOI: 10.1136/bcr-2016-217092
PMCID: PMC5093848
PMID: 27789547
Abstract
Successful vitamin K antagonist (eg, warfarin) reversal with 4-factor prothrombin complex concentrate (4F-PCC) without vitamin K (phytonadione) for emergent surgery in a patient at moderate-to-high risk for thromboembolism is reported. This approach may decrease the risk for development of thrombus, as it limits the amount of time the patient's anticoagulation is subtherapeutic. It also may increase the risk of bleeding, so patient selection is essential if this strategy is employed. Caution must be exercised to complete the procedure or surgery in the window of peak 4F-PCC effect (∼1–6 hours postinfusion).
Details
- Title: Subtitle
- Reversal of anticoagulation with four-factor prothrombin complex concentrate without concurrent vitamin K (phytonadione) for urgent surgery in a patient at moderate-to-high risk for thromboembolism
- Creators
- Thomas Michael Farley - Mercy Iowa City (Iowa City)Elisha M Andreas - University of Iowa
- Resource Type
- Journal article
- Publication Details
- BMJ case reports, Vol.2016, p.bcr2016217092
- DOI
- 10.1136/bcr-2016-217092
- PMID
- 27789547
- PMCID
- PMC5093848
- ISSN
- 1757-790X
- eISSN
- 1757-790X
- Language
- English
- Date published
- 10/27/2016
- Academic Unit
- Pharmacy Practice and Science
- Record Identifier
- 9984365901302771
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