Journal article
Reversal of left ventricular dysfunction after ablation of premature ventricular contractions related parameters, paradoxes and exceptions to the rule
International journal of cardiology, Vol.222, pp.31-36
11/01/2016
DOI: 10.1016/j.ijcard.2016.07.005
PMID: 27448702
Abstract
Suppression of frequent premature ventricular contractions (PVCs) does not systematically lead to an expected reversal of PVC-induced cardiomyopathy and determinants of left ventricular ejection fraction (LVEF) recovery (reverse remodeling) after ablation remain largely unknown.
Ninety-six consecutive patients with a suspicion of PVC induced-cardiomyopathy were retrospectively included. Parameters potentially related to reverse remodeling (>10% increase in LVEF) were analyzed in patients w/wo long-term success (decrease in PVC burden >80%).
Over a mean follow-up of 24±21months, long-term ablation success was obtained in 76 patients (79%). In these, reverse remodeling was observed in 63 (83%) (LVEF 39±8 to 56±8%, p<0.0001). In multivariate analysis, only an older age (and marginally a lower PVC QRS amplitude) was independently associated with the lack of reverse remodeling. Only 10 of the 35 patients who initially should have received an ICD for primary prevention remained candidates for implantation after ablation. Lack of reverse remodeling was significantly linked to a higher mortality.
Reverse remodeling was observed in 83% of patients with frequent PVC and unexplained cardiomyopathy undergoing long-term successful ablation of the PVC. A younger age was independently correlated with the occurrence of reverse remodeling.
Details
- Title: Subtitle
- Reversal of left ventricular dysfunction after ablation of premature ventricular contractions related parameters, paradoxes and exceptions to the rule
- Creators
- Marie Sadron Blaye-Felice - University Hospital Rangueil Toulouse, FranceDavid Hamon - University of Iowa, Internal MedicineFrederic Sacher - Hôpital Cardiologique du Haut-LévêquePatrizio Pascale - Hôpital Orthopédique de la Suisse RomandeAnne Rollin - Hôpital RangueilVanina Bongard - Hôpital RangueilAlexandre Duparc - Hôpital RangueilPierre Mondoly - Hôpital RangueilNicolas Derval - Hôpital Cardiologique du Haut-LévêqueArnaud Denis - Hôpital Cardiologique du Haut-LévêqueChristelle Cardin - Hôpital RangueilMélèze Hocini - Hôpital Cardiologique du Haut-LévêquePierre Jaïs - University Hospital Haut-Leveque, Bordeaux-Pessac, FranceEtienne Pruvot - Hôpital Orthopédique de la Suisse RomandeJurg Schlaepfer - Hôpital Orthopédique de la Suisse RomandeDidier Carrié - Hôpital RangueilMichel Galinier - Hôpital RangueilNicolas Lellouche - Hôpitaux Universitaires Henri-MondorMichel Haïssaguerre - University Hospital Haut-Leveque, Bordeaux-Pessac, FrancePhilippe Maury - Hôpital Rangueil
- Resource Type
- Journal article
- Publication Details
- International journal of cardiology, Vol.222, pp.31-36
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ijcard.2016.07.005
- PMID
- 27448702
- ISSN
- 0167-5273
- eISSN
- 1874-1754
- Language
- English
- Date published
- 11/01/2016
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984694744402771
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