Journal article
Reversal of oxidative stress in endothelial cells by controlled release of adiponectin
Journal of controlled release, Vol.130(3), pp.234-237
2008
DOI: 10.1016/j.jconrel.2008.06.009
PMID: 18619503
Abstract
Hyperglycemia causes endothelial dysfunction due to its effect on increasing reactive oxygen species (ROS). Adiponectin (Adp) has been reported to suppress hyperglycemia-associated ROS generation. It was hypothesized that administering globular adiponectin (gAdp) via injectable biodegradable thermosensitive triblock copolymer might effectively reduce ROS generation in endothelial cells. In this study, gAdp was incorporated into and released from the polymer gel. The released gAdp was further investigated by comparing it with the intact gAdp with regard to the efficiency in reducing ROS and activating cAMP. The released gAdp effectively suppressed excess ROS production in the
in vitro endothelial cell culture model under high-glucose condition via cAMP/PKA pathway. These data provide a rationale for developing controlled release dosage form of gAdp as a therapeutic tool for oxidative stress-related pathology in patients with diabetes.
Details
- Title: Subtitle
- Reversal of oxidative stress in endothelial cells by controlled release of adiponectin
- Creators
- Mohanad Mossalam - Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USAJi-Hoon Jeong - Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USAE. Dale Abel - Program in Human Molecular Biology and Genetics, Department of Internal Medicine, University of Utah, USASung Wan Kim - Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USAYong-Hee Kim - Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA
- Resource Type
- Journal article
- Publication Details
- Journal of controlled release, Vol.130(3), pp.234-237
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.jconrel.2008.06.009
- PMID
- 18619503
- ISSN
- 0168-3659
- eISSN
- 1873-4995
- Language
- English
- Date published
- 2008
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984025257902771
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