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Reversibility of Murine Motor Deficits Following Hemi-Craniectomy and Cranioplasty
Journal article   Peer reviewed

Reversibility of Murine Motor Deficits Following Hemi-Craniectomy and Cranioplasty

Brian T Andrews, Anna Lydick, Scott Barbay, Peter Reisz and Randolph J Nudo
The Journal of craniofacial surgery, Vol.27(7), pp.1875-1878
10/2016
DOI: 10.1097/SCS.0000000000002897
PMCID: PMC5065373
PMID: 27438444
url
https://www.ncbi.nlm.nih.gov/pmc/articles/5065373View
Open Access

Abstract

Hemi-craniectomy is a common surgical procedure which allows the brain to swell and herniate and is often utilized to treat traumatic brain injury. When left untreated the scalp skin typically sinks on the side of the craniectomy creating a phenotype termed "sinking skin flap syndrome." In addition, these same patients often develop long-term neurocognitive deficits termed "syndrome of the trephined" as a result of their craniectomy which reverse when the cranial skull is replaced. The authors hypothesize that a mouse animal model can be developed demonstrating long-term neurologic deficits attributed to hemi-craniectomy skull defects similar to humans with syndrome of the trephined. Thirty C57 mice were randomized among 3 groups: Group 1 = control group (sham surgery), Group 2 = hemi-craniectomy only, and Group 3 = hemi-craniectomy with immediate cranioplasty. Motor deficits were studied using a beam walk test. Statistical comparison of differences among the 3 groups was performed. Beam walk test results demonstrated the craniectomy group had a statistically higher contralateral footfault slip/step ratio when compared with the control group (P <0.05). Comparison of the control group and the cranioplasty group demonstrated contralateral footfault slip/step ratio that was statistically different for 7 days postoperative but no statistical differences thereafter. Comparison of the craniectomy group and the cranioplasty group demonstrated statistically significant differences for 14 days; however, motor deficits were not statistically different than baseline thereafter. No ipsilateral footfault deficits were detected in this study. Motor deficits that are attributed to hemi-craniectomy bone defects alone are demonstrated in a mouse animal model. These motor deficits resemble some symptoms associated with human syndrome of the trephined.
 Motor Activity - physiology Animals Mice, Inbred C57BL Brain Injuries - surgery Mice Brain Injuries - physiopathology Recovery of Function Decompressive Craniectomy - methods Disease Models, Animal

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