Journal article
Reversible depression of the reticuloendothelial system by liposomes
Biochimica et biophysica acta. General subjects, Vol.714(3), pp.479-485
1982
DOI: 10.1016/0304-4165(82)90157-X
PMID: 7059613
Abstract
The effect of various doses of different types (reverse phase evaporation vesicles and small unilamellar vesicles) of intravenously injected liposomes on reticuloendothelial activity, as measured by the blood clearance rate of intravenously injected carbon, was investigated. Also the effect of pretreatment with reverse phase evaporation vesicles on blood clearance and tissue distribution of a second dose of similar vesicles was determined. For all concentrations used reverse phase evaporation vesicles caused reduction in reticuloendothelial activity at least up to 4 h after injection. 24 h after administration the rate of carbon clearance returned to the control level. On the contrary small unilamellar vesicles did not block reticuloendothelial activity. Pretreatment with reverse phase evaporation vesicles (250 μmol/kg) caused an increased blood level and a decreased hepatic uptake of a second dose of the vesicles, injected 1 h after the first dose. This seems to be due to a depression of reticuloendothelial activity and not to a depletion of opsonins. Pretreatment with small unilamellar vesicles (250 μmol/kg) had no significant influence on the tissue distribution of a second dose of vesicles. Our results clearly indicate that reverse phase evaporation vesicles cause a reversible depression of reticuloendothelial activity and this depression seems to be induced by a saturation of reticuloendothelial cells with liposomes.
Details
- Title: Subtitle
- Reversible depression of the reticuloendothelial system by liposomes
- Creators
- Harma Ellens - University at Buffalo, State University of New YorkEric Mayhew - University at Buffalo, State University of New YorkYoucef M. Rustum - Roswell Park Cancer Institute
- Resource Type
- Journal article
- Publication Details
- Biochimica et biophysica acta. General subjects, Vol.714(3), pp.479-485
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0304-4165(82)90157-X
- PMID
- 7059613
- ISSN
- 0304-4165
- eISSN
- 1872-8006
- Language
- English
- Date published
- 1982
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984360052102771
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