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Reversible renal insufficiency secondary to extrinsic splenic compression of the kidney in a patient with chronic lymphocytic leukemia
Journal article   Open access   Peer reviewed

Reversible renal insufficiency secondary to extrinsic splenic compression of the kidney in a patient with chronic lymphocytic leukemia

Miriam Hadj-Moussa and James A Brown
TheScientificWorld, Vol.10, pp.796-798
05/04/2010
DOI: 10.1100/tsw.2010.74
PMCID: PMC5763834
PMID: 20454760
url
https://doi.org/10.1100/tsw.2010.74View
Published (Version of record) Open Access

Abstract

While increased renal venous and direct renal parenchymal pressure may cause renal insufficiency, there are no prior reports of hypersplenism secondary to chronic lymphocytic leukemia (CLL) doing so. This first report of massive splenomegaly leading to marked compression of the left kidney associated with renal insufficiency that resolved after splenectomy illustrates that profound extrinsic renal compression from splenomegaly may significantly compromise left renal function and splenectomy should be considered in this situation.
Aged Humans Kidney - physiopathology Leukemia, Lymphocytic, Chronic, B-Cell - physiopathology Male Radiography, Abdominal Renal Insufficiency - complications Renal Insufficiency - physiopathology Spleen - physiopathology Tomography, X-Ray Computed

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