Reversible severe ovarian enlargement in an infant with significant insulin resistance

Lillian Lai; Amir Mikhchi; Anna Ryabets-Lienhard; Mitchell E Geffner; Clement Cheung; Danielle Guiffre

doi:10.1016/j.radcr.2021.03.067

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Reversible severe ovarian enlargement in an infant with significant insulin resistance

Journal article

Open access

Peer reviewed

Reversible severe ovarian enlargement in an infant with significant insulin resistance

Lillian Lai, Amir Mikhchi, Anna Ryabets-Lienhard, Mitchell E Geffner, Clement Cheung and Danielle Guiffre

Radiology case reports, Vol.16(7), pp.1760-1765

05/01/2021

DOI: 10.1016/j.radcr.2021.03.067

PMCID: PMC8111256

PMID: 34007398

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Abstract

The extent, severity, and radiological findings of ovarian growth in infants with genetic syndromes of insulin resistance have not been fully described. We report a rare case of reversible massive ovarian enlargement in a female infant with a congenital insulin resistance syndrome, likely Rabson-Mendenhall syndrome given the less clinically severe course. The patient presented with neonatal diabetes with hyperinsulinemia and hyperglycemia due to congenital insulin resistance. She developed increasing severe bilateral ovarian enlargement which peaked at 4 months of age, followed by gradual decrease in size of the ovaries following treatment with insulin-sensitizing drugs and improved hyperinsulinemia. The ovarian enlargement is postulated to be secondary to the trophic effects of insulin acting in a gonadotropin-independent mechanism. Hyperinsulinemia in congenital insulin resistance can also result in hypertrophy of other organs. Understanding the pathophysiology behind massive ovarian enlargement in the setting of congenital insulin resistance syndromes can help guide appropriate therapy.

Donohue

Enlargement

Insulin resistance

Ovarian

Pediatric

Rabson-Mendenhall

Details

Title: Subtitle: Reversible severe ovarian enlargement in an infant with significant insulin resistance
Creators: Lillian Lai - Children's Hospital of Los Angeles
Amir Mikhchi - Children's Hospital of Los Angeles
Anna Ryabets-Lienhard - Children's Hospital of Los Angeles
Mitchell E Geffner - Division of Endocrinology, Children's Hospital Los Angeles and University of Southern California, Keck School of Medicine, Los Angeles, CA, USA The Saban Research Institute, Children's Hospital Los Angeles and University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
Clement Cheung - Children's Hospital of Los Angeles
Danielle Guiffre - Children's Hospital of Los Angeles
Resource Type: Journal article
Publication Details: Radiology case reports, Vol.16(7), pp.1760-1765
DOI: 10.1016/j.radcr.2021.03.067
PMID: 34007398
PMCID: PMC8111256
NLM abbreviation: Radiol Case Rep
ISSN: 1930-0433
eISSN: 1930-0433
Publisher: Elsevier
Language: English
Date published: 05/01/2021
Academic Unit: Radiology
Record Identifier: 9984318691702771

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