Review of Pediatric Osteoarticular Infections

Derek Zhorne; Kathleen Kilroy Bradford; Ravi Jhaveri

doi:10.2174/1574887112666170828120040

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Review of Pediatric Osteoarticular Infections

Journal article

Peer reviewed

Review of Pediatric Osteoarticular Infections

Derek Zhorne, Kathleen Kilroy Bradford and Ravi Jhaveri

Reviews on recent clinical trials, Vol.12(4), pp.260-268

2017

DOI: 10.2174/1574887112666170828120040

PMID: 28847286

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Abstract

Pediatric osteoarticular infections are relatively rare but important diseases to identify early and treat appropriately in order to avoid associated acute complications or long-term morbidity. To review the current epidemiology and etiology of pediatric osteoarticular infections as well as recent advances in the diagnosis and treatment of these infections. We searched PubMed (MEDLINE) and Scopus databases for potentially relevant publications in the past 5 years. Bacterial epidemiology and antimicrobial resistance profiles vary greatly worldwide, although Staphylococcus aureus, streptococci and Kingella kingae are the predominant pathogens. There is emerging evidence supporting the role of PCR assays for pathogen detection. Current data suggest that most children with osteoarticular infections can be successfully transitioned to oral antibiotics after having received at least several days of intravenous therapy, undergone removal of significant infectious foci and having demonstrated clinical improvement with down trending inflammatory markers. The optimal length and route of antimicrobial therapy have not been fully elucidated and should depend on individual patient factors, the virulence of the pathogen and the monitored clinical and laboratory response to therapy.

Child

Disease Management

Global Health

Humans

Incidence

Osteoarthritis - diagnosis

Osteoarthritis - epidemiology

Osteoarthritis - therapy

Details

Title: Subtitle: Review of Pediatric Osteoarticular Infections
Creators: Derek Zhorne - University of Iowa
Kathleen Kilroy Bradford - Division of General Pediatrics and Adolescent Medicine. United States.
Ravi Jhaveri - University of North Carolina at Chapel Hill
Resource Type: Journal article
Publication Details: Reviews on recent clinical trials, Vol.12(4), pp.260-268
DOI: 10.2174/1574887112666170828120040
PMID: 28847286
ISSN: 1574-8871
eISSN: 1876-1038
Language: English
Date published: 2017
Academic Unit: Stead Family Department of Pediatrics; Hospital Medicine
Record Identifier: 9984353825202771

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