Journal article
Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma
Frontiers in oncology, Vol.12, p.1057930
11/17/2022
DOI: 10.3389/fonc.2022.1057930
PMID: 36465353
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal types of solid tumors, associated with a high prevalence of cachexia ( 80%). PDAC-derived cachexia (PDAC-CC) is a systemic disease involving the complex interplay between the tumor and multiple organs. The endocrine organ–like tumor (EOLT) hypothesis may explain the systemic crosstalk underlying the deleterious homeostatic shifts that occur in PDAC-CC. Several studies have reported a markedly heterogeneous collection of cachectic mediators, signaling mechanisms, and metabolic pathways, including exocrine pancreatic insufficiency, hormonal disturbance, pro-inflammatory cytokine storm, digestive and tumor-derived factors, and PDAC progression. The complexities of PDAC-CC necessitate a careful review of recent literature summarizing cachectic mediators, corresponding metabolic functions, and the collateral impacts on wasting organs. The EOLT hypothesis suggests that metabolites, genetic instability, and epigenetic changes (microRNAs) are involved in cachexia development. Both tumors and host tissues can secrete multiple cachectic factors (beyond only inflammatory mediators). Some regulatory molecules, metabolites, and microRNAs are tissue-specific, resulting in insufficient energy production to support tumor/cachexia development. Due to these complexities, changes in a single factor can trigger bi-directional feedback circuits that exacerbate PDAC and result in the development of irreversible cachexia. We provide an integrated review based on 267 papers and 20 clinical trials from PubMed and ClinicalTrials.gov database proposed under the EOLT hypothesis that may provide a fundamental understanding of cachexia development and response to current treatments.
Details
- Title: Subtitle
- Review of the endocrine organ–like tumor hypothesis of cancer cachexia in pancreatic ductal adenocarcinoma
- Creators
- Ying-Chun Yu - , , , , , , , , , , , ,Azaj Ahmed - China Medical UniversityHsueh-Chou Lai - , , , , , , , , , , , ,Wei-Chung Cheng - , , , , , , , , , , , ,Juan-Chern Yang - China Medical UniversityWei-Chun Chang - , , , , , , , , , , , ,Lu-Min Chen - , , , , , , , , , , , ,Yan-Shen Shan - , , , , , , , , , , , ,Wen-Lung Ma - , , , , , , , , , , , ,
- Resource Type
- Journal article
- Publication Details
- Frontiers in oncology, Vol.12, p.1057930
- DOI
- 10.3389/fonc.2022.1057930
- PMID
- 36465353
- NLM abbreviation
- Front Oncol
- ISSN
- 2234-943X
- eISSN
- 2234-943X
- Publisher
- Frontiers Media S.A
- Grant note
- ;
- Language
- English
- Date published
- 11/17/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985178663802771
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