Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects

Min Shi; George L Wehby; Jeffrey C Murray

doi:10.1002/bdrc.20117

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Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects

Journal article

Open access

Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects

Min Shi, George L Wehby and Jeffrey C Murray

Birth defects research. Part C. Embryo today, Vol.84(1), pp.16-29

03/2008

DOI: 10.1002/bdrc.20117

PMCID: PMC2570345

PMID: 18383123

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Abstract

A spectrum of adverse pregnancy outcomes, including preterm birth, low birth weight, and birth defects has been linked with maternal smoking during pregnancy. This article includes a review of studies investigating interactions between genetic variants and maternal smoking in contributing to birth defects using oral clefting as a model birth defect. The primary gene-smoking studies for other major birth defects are also summarized. Gene-environment interaction studies for birth defects are still at an early stage with several mixed results, but evolving research findings have begun to document clinically and developmentally important interactions. As samples and data become increasingly available, more effort is needed in designing innovative analytical methods to study gene-environment interactions.

Pregnancy

Genetic Variation

Genetic Predisposition to Disease

Humans

Pregnancy Complications

Congenital Abnormalities - etiology

Female

Smoking - genetics

Maternal Exposure

Cleft Lip - etiology

Details

Title: Subtitle: Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects
Creators: Min Shi - Biostatistics Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA
George L Wehby
Jeffrey C Murray
Resource Type: Journal article
Publication Details: Birth defects research. Part C. Embryo today, Vol.84(1), pp.16-29
DOI: 10.1002/bdrc.20117
PMID: 18383123
PMCID: PMC2570345
NLM abbreviation: Birth Defects Res C Embryo Today
ISSN: 1542-975X
eISSN: 1542-9768
Publisher: United States
Grant note: P50 DE016215 / NIDCR NIH HHS Intramural NIH HHS P50 DE-16215 / NIDCR NIH HHS R37 DE008559-18 / NIDCR NIH HHS P50 DE016215-04 / NIDCR NIH HHS R37 DE008559 / NIDCR NIH HHS R03 DE018394-01 / NIDCR NIH HHS R01 DD000295 / NCBDD CDC HHS R37 DE-08559 / NIDCR NIH HHS R03 DE018394 / NIDCR NIH HHS 2P30 EY-5605 / NEI NIH HHS 1R01DD000295-01 / NCBDD CDC HHS
Language: English
Date published: 03/2008
Academic Unit: Preventive and Community Dentistry; Anatomy and Cell Biology; Health Management and Policy; Stead Family Department of Pediatrics; Epidemiology; Economics; Pediatric Dentistry; Craniofacial Anomalies Research Center; Public Policy Center (Archive); Dental Research
Record Identifier: 9984025368902771

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