Revisiting Oral Fluoroquinolone and Multivalent Cation Drug-Drug Interactions: Are They Still Relevant?

Stuart K. Pitman; Uyen T. P. Hoang; Caren H. Wi; Mona Alsheikh; Dakota A. Hiner; Kelly M. Percival

doi:10.3390/antibiotics8030108

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Revisiting Oral Fluoroquinolone and Multivalent Cation Drug-Drug Interactions: Are They Still Relevant?

Journal article

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Revisiting Oral Fluoroquinolone and Multivalent Cation Drug-Drug Interactions: Are They Still Relevant?

Stuart K. Pitman, Uyen T. P. Hoang, Caren H. Wi, Mona Alsheikh, Dakota A. Hiner and Kelly M. Percival

Antibiotics (Basel), Vol.8(3), p.108

07/31/2019

DOI: 10.3390/antibiotics8030108

PMCID: PMC6784105

PMID: 31370320

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Abstract

Fluoroquinolones are a widely-prescribed, broad-spectrum class of antibiotics with several oral formulations notable for their high bioavailability. For certain infections, fluoroquinolones are the first line or only treatment choice. When administered orally, fluoroquinolones require proper administration to ensure adequate systemic absorption and, thereby, protect patients from treatment failure. Oral drug preparations that contain multivalent cations are well known to chelate with fluoroquinolones in the gastrointestinal tract; co-administration may lead to clinically significant decreases in oral fluoroquinolone bioavailability and an overall increase in fluoroquinolone-resistant bacteria. Based on a search and evaluation of the literature, this focused review describes oral fluoroquinolone-multivalent cation drug-drug interactions and their magnitude and offers several clinical management strategies for these potentially clinically significant interactions.

antibiotic

cation

drug interaction

fluoroquinolone

oral

resistance

Review

Details

Title: Subtitle: Revisiting Oral Fluoroquinolone and Multivalent Cation Drug-Drug Interactions: Are They Still Relevant?
Creators: Stuart K. Pitman - University of Iowa
Uyen T. P. Hoang - College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA Department of Pharmaceutical Care, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
Caren H. Wi - University of Iowa
Mona Alsheikh - University of Iowa
Dakota A. Hiner - University of Iowa
Kelly M. Percival - University of Iowa
Resource Type: Journal article
Publication Details: Antibiotics (Basel), Vol.8(3), p.108
DOI: 10.3390/antibiotics8030108
PMID: 31370320
PMCID: PMC6784105
NLM abbreviation: Antibiotics (Basel)
ISSN: 2079-6382
eISSN: 2079-6382
Publisher: MDPI
Language: English
Date published: 07/31/2019
Academic Unit: Pharmacy Practice and Science; Applied Clinical Sciences
Record Identifier: 9984366023002771

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