Journal article
Revisiting histidine-dependent acid phosphatases: a distinct group of tyrosine phosphatases
Trends in biochemical sciences (Amsterdam. Regular ed.), Vol.34(6), pp.273-278
06/01/2009
DOI: 10.1016/j.tibs.2009.03.002
PMCID: PMC2775480
PMID: 19467874
Abstract
Although classical protein tyrosine phosphatase (PTP) superfamily members are cysteine-dependent, emerging evidence shows that many acid phosphatases (AcPs) function as histidine-dependent PTPs in vivo. These AcPs dephosphorylate phospho-tyrosine substrates intracellularly and could have roles in development and disease. In contrast to cysteine-dependent PTPs, they utilize histidine, rather than cysteine, for substrate dephosphorylation. Structural analyses reveal that active site histidine, but not cysteine, faces towards the substrate and functions as the phosphate acceptor. Nonetheless, during dephosphorylation, both histidine-dependent and cysteine-dependent PTPs use their active site arginine and aspartate for substrate binding and proton donation, respectively. Thus, we propose that they should be referred to as a distinct group of 'histidine-dependent PTPs' within the PTP superfamily.
Details
- Title: Subtitle
- Revisiting histidine-dependent acid phosphatases: a distinct group of tyrosine phosphatases
- Creators
- Suresh Veeramani - University of Nebraska Medical CenterMing-Shyue Lee - National Taiwan UniversityMing-Fong Lin - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- Trends in biochemical sciences (Amsterdam. Regular ed.), Vol.34(6), pp.273-278
- DOI
- 10.1016/j.tibs.2009.03.002
- PMID
- 19467874
- PMCID
- PMC2775480
- NLM abbreviation
- Trends Biochem Sci
- ISSN
- 0968-0004
- eISSN
- 1362-4326
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- Nebraska Research Initiative University of Nebraska Medical Center LB506 / Nebraska Cancer and Smoking Disease Research Program R01 CA88184 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01CA088184 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) PC074289 / US Department of Defense; United States Department of Defense
- Language
- English
- Date published
- 06/01/2009
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359689502771
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