Journal article
Rhabdomyosarcoma Treatment and Outcome at a Multidisciplinary Pediatric Cancer Center in Lebanon
Pediatric hematology and oncology, Vol.29(4), pp.322-334
05/01/2012
DOI: 10.3109/08880018.2012.676721
PMID: 22568795
Abstract
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Outcome of patients treated on standard protocols, in a multidisciplinary cancer center setting outside of clinical trials, is not well reported. We reviewed characteristics and outcome of 23 pediatric patients treated at a single, multidisciplinary cancer center in Lebanon, between April 2002 and December 2010. Median follow-up was 41 months. The most commonly affected primary site was the head and neck (48%, n = 11). Nineteen tumors (82.6%) were of embryonal histology. Tumor size was ≥5 cm in eight (34.8%) patients. Sixteen patients (69.6%) had localized disease, and one (4.4%) had metastatic disease. Fifteen (65.2%) had Group III tumors. All patients received chemotherapy, for a duration ranging 21-51 weeks. Upfront surgical resection was performed in 10 patients (43.5%). Eighteen patients (78.3%) received radiation therapy. The 5-year overall and disease-free survival rates were 83% and 64%, respectively. Relapse correlated with absence of surgery. Treatment of childhood RMS in a multidisciplinary cancer center in Lebanon results in similar survival to that in developed countries when similar protocols are applied. There was a higher incidence of local relapse, but those were salvageable with further therapy and surgical local control.
Details
- Title: Subtitle
- Rhabdomyosarcoma Treatment and Outcome at a Multidisciplinary Pediatric Cancer Center in Lebanon
- Creators
- Maysaa Salman - American University of BeirutHani Tamim - American University of BeirutFouad Medlej - American University of BeirutTarek El-Ariss - American University of BeirutFatima Saad - American University of BeirutFouad Boulos - American University of BeirutToufic Eid - American University of BeirutSamar Muwakkit - American University of BeirutNabil Khoury - American University of BeirutMiguel Abboud - American University of BeirutRaya Saab - American University of Beirut
- Resource Type
- Journal article
- Publication Details
- Pediatric hematology and oncology, Vol.29(4), pp.322-334
- Publisher
- Informa Healthcare
- DOI
- 10.3109/08880018.2012.676721
- PMID
- 22568795
- ISSN
- 0888-0018
- eISSN
- 1521-0669
- Language
- English
- Date published
- 05/01/2012
- Academic Unit
- Radiology
- Record Identifier
- 9984697721902771
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