Rheological characterization of neutral and anionic polysaccharides with reduced mucociliary transport rates

Ankur J. Shah; Maureen D. Donovan

doi:10.1208/pt0802032

Back

Rheological characterization of neutral and anionic polysaccharides with reduced mucociliary transport rates

Journal article

Open access

Peer reviewed

Rheological characterization of neutral and anionic polysaccharides with reduced mucociliary transport rates

Ankur J. Shah and Maureen D. Donovan

AAPS PharmSciTech, Vol.8(2), pp.E40-E47

04/20/2007

DOI: 10.1208/pt0802032

PMCID: PMC2750371

PMID: 17622110

Files and links (1)

url

https://europepmc.org/articles/pmc2750371View

Published (Version of record) Open Access

Abstract

The purpose of this research was to compare the viscoelastic properties of several neutral and anionic polysaccharide polymers with their mucociliary transport rates (MTR) across explants of ciliated bovine tracheal tissue to identify rheologic parameters capable of predicting the extent of reduction in mucociliary transport. The viscoelastic properties of the polymer gels and gels mixed with mucus were quantified using controlled stress rheometry. In general, the anionic polysaccharides were more efficient at decreasing the mucociliary transport rate than were the neutral polymers, and a concentration threshold, where no further decreases in mucociliary transport occurred with increasing polymer concentration, was observed for several of the neutral polysaccharides. No single rheologic parameter (ν, G′, G″, tan δ, G * ) was a good predictor of the extent of mucociliary transport reduction, but a combination of the apparent viscosity (ν), tangent to the phase angle (tan δ), and complex modulus (G * ) was found to be useful in the identification of formulations capable of decreasing MTR. The relative values of each of the rheologic parameters were unique for each polymer, yet once the relationships between the rheologic parameters and mucociliary transport rate reduction were determined, formulations capable of resisting mucociliary clearance could be rapidly optimized.

alginate

carboxymethylcellulose

hydroxypropyl methylcellulose

methylcellulose

Mucociliary clearance

rheology

xanthan

Details

Title: Subtitle: Rheological characterization of neutral and anionic polysaccharides with reduced mucociliary transport rates
Creators: Ankur J. Shah - University of Iowa
Maureen D. Donovan - University of Iowa
Resource Type: Journal article
Publication Details: AAPS PharmSciTech, Vol.8(2), pp.E40-E47
DOI: 10.1208/pt0802032
PMID: 17622110
PMCID: PMC2750371
NLM abbreviation: AAPS PharmSciTech
ISSN: 1530-9932
eISSN: 1530-9932
Publisher: Springer-Verlag
Language: English
Date published: 04/20/2007
Academic Unit: Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984366034402771

Metrics

5 Record Views

5 Times Cited - Web of Science