Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN

Li Wu; Arman A Bashirova; Thomas D Martin; Loreley Villamide; Erin Mehlhop; Andrei O Chertov; Derya Unutmaz; Melissa Pope; Mary Carrington; Vineet N KewalRamani

doi:10.1073/pnas.032654399

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Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN

Journal article

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Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN

Li Wu, Arman A Bashirova, Thomas D Martin, Loreley Villamide, Erin Mehlhop, Andrei O Chertov, Derya Unutmaz, Melissa Pope, Mary Carrington and Vineet N KewalRamani

Proceedings of the National Academy of Sciences - PNAS, Vol.99(3), pp.1568-1573

02/05/2002

DOI: 10.1073/pnas.032654399

PMCID: PMC122231

PMID: 11818554

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Abstract

Here, we describe the isolation and characterization of the rhesus macaque homolog for human DC-SIGN, a dendritic cell-specific C-type lectin. mac-DC-SIGN is 92% identical to hu-DC-SIGN. mac-DC-SIGN preserves the virus transmission function of hu-DC-SIGN, capturing and efficiently transducing simian and human immunodeficiency virus to target CD4 + T cells. Surprisingly, however, mac-DC-SIGN plays no discernable role in the ability of rhesus macaque dendritic cells to capture and transmit primate lentiviruses. Expression and neutralization analyses suggest that this process is DC-SIGN independent in macaque, although the participation of other lectin molecules cannot be ruled out. The ability of primate lentiviruses to effectively use human and rhesus dendritic cells in virus transmission without the cells becoming directly infected suggests that these viruses have taken advantage of a conserved dendritic cell mechanism in which DC-SIGN family molecules are significant contributors but not the only participants.

Biological Sciences

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Title: Subtitle: Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN
Creators: Li Wu - Vanderbilt University, School of Medicine, Nashville, TN 37232
Arman A Bashirova - Vanderbilt University, School of Medicine, Nashville, TN 37232
Thomas D Martin - Vanderbilt University, School of Medicine, Nashville, TN 37232
Loreley Villamide - Vanderbilt University, School of Medicine, Nashville, TN 37232
Erin Mehlhop - Vanderbilt University, School of Medicine, Nashville, TN 37232
Andrei O Chertov - Vanderbilt University, School of Medicine, Nashville, TN 37232
Derya Unutmaz - Vanderbilt University, School of Medicine, Nashville, TN 37232
Melissa Pope - Vanderbilt University, School of Medicine, Nashville, TN 37232
Mary Carrington - Vanderbilt University, School of Medicine, Nashville, TN 37232
Vineet N KewalRamani - Vanderbilt University, School of Medicine, Nashville, TN 37232
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.99(3), pp.1568-1573
DOI: 10.1073/pnas.032654399
PMID: 11818554
PMCID: PMC122231
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 02/05/2002
Academic Unit: Microbiology and Immunology
Record Identifier: 9984001112802771

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