Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease

Christine L Wohlford-Lenane; David K Meyerholz; Stanley Perlman; Haixia Zhou; Dat Tran; Michael E Selsted; Paul B McCray Jr

doi:10.1128/JVI.01363-09

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Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease

Journal article

Open access

Peer reviewed

Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease

Christine L Wohlford-Lenane, David K Meyerholz, Stanley Perlman, Haixia Zhou, Dat Tran, Michael E Selsted and Paul B McCray Jr

Journal of virology, Vol.83(21), pp.11385-11390

11/2009

DOI: 10.1128/JVI.01363-09

PMCID: PMC2772759

PMID: 19710146

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https://europepmc.org/articles/pmc2772759View

Published (Version of record) Open Access

Abstract

We evaluated the efficacy of rhesus theta-defensin 1 (RTD-1), a novel cyclic antimicrobial peptide, as a prophylactic antiviral in a mouse model of severe acute respiratory syndrome (SARS) coronavirus (CoV) lung disease. BALB/c mice exposed to a mouse-adapted strain of SARS-CoV demonstrated 100% survival and modest reductions in lung pathology without reductions in virus titer when treated with two intranasal doses of RTD-1, while mortality in untreated mice was approximately 75%. RTD-1-treated, SARS-CoV-infected mice displayed altered lung tissue cytokine responses 2 and 4 days postinfection compared to those of untreated animals, suggesting that one possible mechanism of action for RTD-1 is immunomodulatory.

Lung - pathology

Severe Acute Respiratory Syndrome - virology

Humans

Lung Diseases - prevention & control

Lung Diseases - drug therapy

Severe Acute Respiratory Syndrome - drug therapy

SARS Virus - pathogenicity

Lung - virology

Lung Diseases - virology

Macaca mulatta - metabolism

Severe Acute Respiratory Syndrome - prevention & control

Animals

Survival Analysis

Defensins - therapeutic use

Mice

Mice, Inbred BALB C

Lung - immunology

Disease Models, Animal

Details

Title: Subtitle: Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease
Creators: Christine L Wohlford-Lenane - Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
David K Meyerholz
Stanley Perlman
Haixia Zhou
Dat Tran
Michael E Selsted
Paul B McCray Jr
Resource Type: Journal article
Publication Details: Journal of virology, Vol.83(21), pp.11385-11390
DOI: 10.1128/JVI.01363-09
PMID: 19710146
PMCID: PMC2772759
NLM abbreviation: J Virol
ISSN: 0022-538X
eISSN: 1098-5514
Publisher: United States
Grant note: R37 AI022931 / NIAID NIH HHS R37AI022931 / NIAID NIH HHS R01 AI058129 / NIAID NIH HHS P01 AI060699 / NIAID NIH HHS R01AI058129 / NIAID NIH HHS
Language: English
Date published: 11/2009
Academic Unit: Microbiology and Immunology; Pulmonary Medicine; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777348102771

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