Journal article
Rheumatoid arthritis: Nuclear medicine state-of-the-art imaging
World journal of orthopedics, Vol.5(3), pp.312-318
07/18/2014
DOI: 10.5312/wjo.v5.i3.312
PMCID: PMC4095024
PMID: 25035834
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease, which is associated with systemic and chronic inflammation of the joints, resulting in synovitis and pannus formation. For several decades, the assessment of RA has been limited to conventional radiography, assisting in the diagnosis and monitoring of disease. Nevertheless, conventional radiography has poor sensitivity in the detection of the inflammatory process that happens in the initial stages of RA. In the past years, new drugs that significantly decrease the progression of RA have allowed a more efficient treatment. Nuclear Medicine provides functional assessment of physiological processes and therefore has significant potential for timely diagnosis and adequate follow-up of RA. Several single photon emission computed tomography (SPECT) and positron emission tomography (PET) radiopharmaceuticals have been developed and applied in this field. The use of hybrid imaging, which permits computed tomography (CT) and nuclear medicine data to be acquired and fused, has increased even more the diagnostic accuracy of Nuclear Medicine by providing anatomical localization in SPECT/CT and PET/CT studies. More recently, fusion of PET with magnetic resonance imaging (PET/MRI) was introduced in some centers and demonstrated great potential. In this article, we will review studies that have been published using Nuclear Medicine for RA and examine key topics in the area. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
Details
- Title: Subtitle
- Rheumatoid arthritis: Nuclear medicine state-of-the-art imaging
- Creators
- Paulo Henrique Rosado-de-Castro - Universidade Federal do Rio de JaneiroSergio Augusto Lopes de Souza - Univ Fed Rio de Janeiro, Dept Radiol, Hosp Univ Clementino Fraga Filho, BR-21941913 Rio De Janeiro, BrazilDangelo Alexandre - Inst Nacl Traumatol & Ortopedia, BR-20940070 Rio De Janeiro, BrazilLea Mirian Barbosa da Fonseca - Univ Fed Rio de Janeiro, Dept Radiol, Hosp Univ Clementino Fraga Filho, BR-21941913 Rio De Janeiro, BrazilBianca Gutfilen - Federal Reserve
- Resource Type
- Journal article
- Publication Details
- World journal of orthopedics, Vol.5(3), pp.312-318
- DOI
- 10.5312/wjo.v5.i3.312
- PMID
- 25035834
- PMCID
- PMC4095024
- NLM abbreviation
- World J Orthop
- ISSN
- 2218-5836
- eISSN
- 2218-5836
- Publisher
- Baishideng Publishing Group Inc
- Number of pages
- 7
- Language
- English
- Date published
- 07/18/2014
- Academic Unit
- Radiology
- Record Identifier
- 9985143552102771
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