Journal article
Right Anterior Cingulate: A Neuroanatomical Correlate of Aggression and Defiance in Boys
Behavioral neuroscience, Vol.122(3), pp.677-684
06/2008
DOI: 10.1037/0735-7044.122.3.677
PMID: 18513137
Abstract
Variation in
emotional processes may contribute to aggressive and defiant behavior. This
study assessed these problem behaviors in a large sample of children and
adolescents in relation to the volume of two cortical regions with prominent
roles in emotion processing, the anterior cingulate cortex (ACC) and
ventromedial prefrontal cortex (vmPFC). One hundred seventeen participants (61
boys, 56 girls), ages 7-17, were recruited from the community.
Aggressive and defiant behavior was measured using the parent- and
teacher-reported Pediatric Behavior Scale and volumetric measures were generated
using structural MRI. Regression analyses indicated a significant sex X ACC
volume interaction in predicting aggressive and defiant behavior, without
significant results for the vmPFC. Follow-up analyses showed that aggressive and
defiant behavior is associated with decreased right ACC volume in boys and a
nonsignificant reduction in left ACC volume in girls. These results are
consistent with the notion that the right ACC acts as a neuroanatomical
correlate of aggression and defiance in boys. The authors discuss this finding
in light of its implications for understanding the neural correlates of
antisocial behavior.
Details
- Title: Subtitle
- Right Anterior Cingulate: A Neuroanatomical Correlate of Aggression and Defiance in Boys
- Creators
- Aaron D Boes - Department of Psychiatry and Medical Scientist Training Program, University of Iowa Carver College of MedicineDaniel Tranel - Department of Neurology (Division of Behavioral Neurology and Cognitive Neuroscience), University of IowaSteven W Anderson - Department of Neurology (Division of Behavioral Neurology and Cognitive Neuroscience), University of IowaPeg Nopoulos - Department of Psychiatry, University of Iowa Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.122(3), pp.677-684
- DOI
- 10.1037/0735-7044.122.3.677
- PMID
- 18513137
- NLM abbreviation
- Behav Neurosci
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Publisher
- American Psychological Association
- Grant note
- DOI: 10.13039/100000072, name: National Institute of Dental and Craniofacial Research, award: 1 RO1 DE01 14399 01 A1; DOI: 10.13039/100000026, name: National Institute on Drug Abuse, award: R01 DA022549; DOI: 10.13039/100000065, name: National Institute of Neurological Disorders and Stroke, award: P01 NS19632
- Language
- English
- Date published
- 06/2008
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984002469102771
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