Journal article
Right atrial stretch alters fore- and hind-brain expression of c-fos and inhibits the rapid onset of salt appetite
The Journal of physiology, Vol.586(Pt 15), pp.3719-3729
08/01/2008
DOI: 10.1113/jphysiol.2008.151282
PMCID: PMC2538823
PMID: 18556369
Abstract
The inflation of an intravascular balloon positioned at the superior vena cava and right atrial junction (SVC-RAJ) reduces sodium or water intake induced by various experimental procedures (e.g. sodium depletion; hypovolaemia). In the present study we investigated if the stretch induced by a balloon at this site inhibits a rapid onset salt appetite, and if this procedure modifies the pattern of immunohistochemical labelling for Fos protein (Fos-ir) in the brain. Male Sprague–Dawley rats with SVC-RAJ balloons received a combined treatment of furosemide (Furo; 10 mg (kg bw)
−1
) plus a low dose of the angiotensin-converting enzyme inhibitor captopril (Cap; 5 mg (kg bw)
−1
). Balloon inflation greatly decreased the intake of 0.3
m
NaCl for as long as the balloon was inflated. Balloon inflation over a 3 h period following Furo–Cap treatment decreased Fos-ir in the organum vasculosum of the lamina terminalis and the subfornical organ and increased Fos-ir in the lateral parabrachial nucleus and caudal ventrolateral medulla. The effect of balloon inflation was specific for sodium intake because it did not affect the drinking of diluted sweetened condensed milk. Balloon inflation and deflation also did not acutely change mean arterial pressure. These results suggest that activity in forebrain circumventricular organs and in hindbrain putative body fluid/cardiovascular regulatory regions is affected by loading low pressure mechanoreceptors at the SVC-RAJ, a manipulation that also attenuates salt appetite.
Details
- Title: Subtitle
- Right atrial stretch alters fore- and hind-brain expression of c-fos and inhibits the rapid onset of salt appetite
- Creators
- Juliana Irani Fratucci De Gobbi - Department of Psychology, University of Iowa Department of Physiology and Pathology, School of Dentistry, Paulista State University (UNESP) Department of Physiology, Bioscience Institute, Paulista State University (UNESP)Jose Vanderlei Menani - Department of Physiology and Pathology, School of Dentistry, Paulista State University (UNESP)Terry G Beltz - Department of Psychology, University of IowaRalph F Johnson - Department of Psychology, University of IowaRobert L Thunhorst - Department of Psychology, University of Iowa Department of Cardiovascular Center, University of IowaAlan Kim Johnson - Department of Psychology, University of Iowa Department of Integrative Physiology, University of Iowa Department of Pharmacology, University of Iowa Department of Cardiovascular Center, University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of physiology, Vol.586(Pt 15), pp.3719-3729
- DOI
- 10.1113/jphysiol.2008.151282
- PMID
- 18556369
- PMCID
- PMC2538823
- NLM abbreviation
- J Physiol
- ISSN
- 0022-3751
- eISSN
- 1469-7793
- Publisher
- Blackwell Science Inc
- Language
- English
- Date published
- 08/01/2008
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
- Record Identifier
- 9984213416602771
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