Right inferior frontal gyrus damage is associated with impaired initiation of inhibitory control, but not its implementation

Yoojeong Choo; Dora Matzke; Mark D Bowren Jr; Daniel Tranel; Jan R Wessel

doi:10.7554/eLife.79667

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Right inferior frontal gyrus damage is associated with impaired initiation of inhibitory control, but not its implementation

Journal article

Open access

Peer reviewed

Right inferior frontal gyrus damage is associated with impaired initiation of inhibitory control, but not its implementation

Yoojeong Choo, Dora Matzke, Mark D Bowren Jr, Daniel Tranel and Jan R Wessel

eLife, Vol.11, e79667

12/30/2022

DOI: 10.7554/eLife.79667

PMCID: PMC9803357

PMID: 36583378

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Abstract

Inhibitory control is one of the most important control functions in the human brain. Much of our understanding of its neural basis comes from seminal work showing that lesions to the right inferior frontal gyrus (rIFG) increase stop-signal reaction time (SSRT), a latent variable that expresses the speed of inhibitory control. However, recent work has identified substantial limitations of the SSRT method. Notably, SSRT is confounded by trigger failures: stop-signal trials in which inhibitory control was never initiated. Such trials inflate SSRT, but are typically indicative of attentional, rather than inhibitory deficits. Here, we used hierarchical Bayesian modeling to identify stop-signal trigger failures in human rIFG lesion patients, non-rIFG lesion patients, and healthy comparisons. Furthermore, we measured scalp-EEG to detect β-bursts, a neurophysiological index of inhibitory control. rIFG lesion patients showed a more than fivefold increase in trigger failure trials and did not exhibit the typical increase of stop-related frontal β-bursts. However, on trials in which such β-bursts did occur, rIFG patients showed the typical subsequent upregulation of β over sensorimotor areas, indicating that their ability to implement inhibitory control, once triggered, remains intact. These findings suggest that the role of rIFG in inhibitory control has to be fundamentally reinterpreted.

Magnetic Resonance Imaging

Bayes Theorem

Frontal Lobe - physiology

Humans

Prefrontal Cortex

Reaction Time - physiology

Sensorimotor Cortex

Details

Title: Subtitle: Right inferior frontal gyrus damage is associated with impaired initiation of inhibitory control, but not its implementation
Creators: Yoojeong Choo - Cognitive Control Collaborative, University of Iowa, Iowa City, United States
Dora Matzke - University of Amsterdam
Mark D Bowren Jr - Department of Clinical and Health Psychology, University of Florida, Gainesville, United States
Daniel Tranel - University of Iowa
Jan R Wessel - University of Iowa
Resource Type: Journal article
Publication Details: eLife, Vol.11, e79667
DOI: 10.7554/eLife.79667
PMID: 36583378
PMCID: PMC9803357
NLM abbreviation: Elife
ISSN: 2050-084X
eISSN: 2050-084X
Grant note: R01 NS117753 / NINDS NIH HHS
Language: English
Date published: 12/30/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984355058202771

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