Journal article
Right inferior longitudinal fasciculus lesions disrupt visual-emotional integration
Social cognitive and affective neuroscience, Vol.11(6), pp.945-951
06/2016
DOI: 10.1093/scan/nsw011
PMCID: PMC4884310
PMID: 26940563
Abstract
The mechanism by which the brain integrates visual and emotional information remains incompletely understood, and can be studied through focal lesions that selectively disrupt this process. To date, three reported cases of visual hypoemotionality, a vision-specific form of derealization, have resulted from lesions of the temporo-occipital junction. We present a fourth case of this rare phenomenon, and investigate the role of the inferior longitudinal fasciculus (ILF) in the underlying pathophysiology. A 50-year-old right-handed male was found to have a right medial temporal lobe tumor following new-onset seizures. Interstitial laser ablation of the lesion was complicated by a right temporo-parieto-occipital intraparenchymal hemorrhage. The patient subsequently experienced emotional estrangement from visual stimuli. A lesion overlap analysis was conducted to assess involvement of the ILF by this patient's lesion and those of the three previously described cases, and diffusion tensor imaging was acquired in our case to further investigate ILF disruption. All four lesions specifically overlapped with the expected trajectory of the right ILF, and diminished structural integrity of the right ILF was observed in our case. These findings implicate the ILF in visual hypoemotionality, suggesting that the ILF is critical for integrating visual information with its emotional content.
Details
- Title: Subtitle
- Right inferior longitudinal fasciculus lesions disrupt visual-emotional integration
- Creators
- David B Fischer - Harvard Medical School, Boston, MA 02115, USA, Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA, dlperez@partners.orgDavid L Perez - Department of Neurology and Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA and Department of PsychiatrySashank Prasad - Department of Neurology, andLaura Rigolo - Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USALauren O'Donnell - Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USADiler Acar - Department of Neurology, andMary-Ellen Meadows - Department of Neurology, andGaston Baslet - Department of PsychiatryAaron D Boes - Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA, Department of Neurology andAlexandra J Golby - Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USABarbara A Dworetzky - Department of Neurology, and
- Resource Type
- Journal article
- Publication Details
- Social cognitive and affective neuroscience, Vol.11(6), pp.945-951
- Publisher
- England
- DOI
- 10.1093/scan/nsw011
- PMID
- 26940563
- PMCID
- PMC4884310
- ISSN
- 1749-5016
- eISSN
- 1749-5024
- Grant note
- P41 EB015898 / NIBIB NIH HHS U01 CA199459 / NCI NIH HHS R25 NS065743 / NINDS NIH HHS
- Language
- English
- Date published
- 06/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984013206202771
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