Journal article
Ringing in the new ear: resolution of cell interactions in otic development
Developmental Biology, Vol.261(2), pp.289-312
2003
DOI: 10.1016/S0012-1606(03)00245-8
PMID: 14499642
Abstract
The vertebrate inner ear is a marvel of structural and functional complexity, which is all the more remarkable because it develops from such a simple structure, the otic placode. Analysis of inner ear development has long been a fascination of experimental embryologists, who sought to understand cellular mechanisms of otic placode induction. More recently, however, molecular and genetic approaches have made the inner ear a useful model system for studying a much broader range of basic developmental mechanisms, including cell fate specification and differentiation, axial patterning, epithelial morphogenesis, cytoskeletal dynamics, stem cell biology, neurobiology, physiology, etc. Of course, there has also been tremendous progress in understanding the functions and processes peculiar to the inner ear. The goal of this review is to recount how historical approaches have shaped our understanding of the signaling interactions controlling early otic development; to discuss how new findings have led to fundamental new insights; and to point out new problems that need to be resolved in future research.
Details
- Title: Subtitle
- Ringing in the new ear: resolution of cell interactions in otic development
- Creators
- Bruce B Riley - Biology Department, Texas A&M University, College Station, TX 77843-3258, USABryan T Phillips - Biology Department, Texas A&M University, College Station, TX 77843-3258, USA
- Resource Type
- Journal article
- Publication Details
- Developmental Biology, Vol.261(2), pp.289-312
- DOI
- 10.1016/S0012-1606(03)00245-8
- PMID
- 14499642
- NLM abbreviation
- Dev Biol
- ISSN
- 0012-1606
- eISSN
- 1095-564X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2003
- Academic Unit
- Biology
- Record Identifier
- 9984217419402771
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