Journal article
Risk Factors Associated With Non-Respondence to Methotrexate in Rheumatoid Arthritis Patients
Curēus (Palo Alto, CA), Vol.13(9), e18112
09/20/2021
DOI: 10.7759/cureus.18112
PMCID: PMC8527277
PMID: 34692323
Abstract
Introduction: Oral methotrexate (MTX) is the first-line therapy for patients with rheumatoid arthritis (RA). However, not all RA patients respond to MTX. In this study, we will determine the risk factors associated with MTX failure. Methods: This retrospective study was conducted in tertiary care hospital in Pakistan. Data of 612 patients who were diagnosed with RA from June 2019 to January 2021 were retrieved from the medical record room. After inclusion, patients were divided into two groups; respondent and non-respondent. Their characteristics and demographics were compared. Results: Out of the total 612 patients, 112 (18.3%) were labelled as non-respondent to MTX. Non-respondents had a higher predominance of females (86.6% vs. 60.2%; p-value: 0.001), participants with body mass index (BMI) >25 kg/m2 (54.4% vs. 22.4%; p-value: <0.00001), smokers (34.8% vs. 18.2%; p-value: 0.0001), participants with diabetes (47.3% vs. 23.4%; p-value: <0.0001) and rheumatoid factor positivity (91.0% vs. 64.8%; p-value: <0.0001). Conclusion: Female gender, higher BMI, smoking, higher disease activity, and diabetes were associated with MTX failure. These easily available parameters can help predict the disease process and outcome of treatment. It is important to screen patients who are at risk of MTX failure, so a contingent treatment plan can be devised, in case patients do not respond to MTX.
Details
- Title: Subtitle
- Risk Factors Associated With Non-Respondence to Methotrexate in Rheumatoid Arthritis Patients
- Creators
- Aman Siddiqui - Bahria UniversityAli Totonchian - Bahria UniversityJamila Begum Jabar AliIshtiaq Ahmad - Khyber Medical CollegeJai Kumar - Jinnah Sindh Medical UniversitySheena Shiwlani - Bahria UniversityDaniya Muhammad HaroonNeeraj Makheja - Bahria UniversityAmber Rizwan - Bahria University
- Resource Type
- Journal article
- Publication Details
- Curēus (Palo Alto, CA), Vol.13(9), e18112
- DOI
- 10.7759/cureus.18112
- PMID
- 34692323
- PMCID
- PMC8527277
- NLM abbreviation
- Cureus
- ISSN
- 2168-8184
- eISSN
- 2168-8184
- Publisher
- Cureus
- Language
- English
- Date published
- 09/20/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985065267902771
Metrics
1 Record Views