Journal article
Risk Factors for Candidal Bloodstream Infections in Surgical Intensive Care Unit Patients: The NEMIS Prospective Multicenter Study
Clinical infectious diseases, Vol.33(2), pp.177-186
07/15/2001
DOI: 10.1086/321811
PMID: 11418877
Abstract
To assess risk factors for development of candidal blood stream infections (CBSIs), a prospective cohort study was performed at 6 sites that involved all patients admitted to the surgical intensive care unit (SICU) for >48 h over a 2-year period. Among 4276 such patients, 42 CBSIs occurred (9.82 CBSIs per 1000 admissions). The overall incidence was 0.98 CBSIs per 1000 patient days and 1.42 per 1000 SICU days with a central venous catheter in place. In multivariate analysis, factors independently associated with increased risk of CBSI included prior surgery (relative risk [RR], 7.3), acute renal failure (RR, 4.2), receipt of parenteral nutrition (RR, 3.6), and, for patients who had undergone surgery, presence of a triple lumen catheter (RR, 5.4). Receipt of an antifungal agent was associated with decreased risk (RR, 0.3). Prospective clinical studies are needed to identify which antifungal agents are most protective and which high-risk patients will benefit from antifungal prophylaxis.
Details
- Title: Subtitle
- Risk Factors for Candidal Bloodstream Infections in Surgical Intensive Care Unit Patients: The NEMIS Prospective Multicenter Study
- Creators
- Henry M Blumberg - Emory UniversityWilliam R Jarvis - Centers for Disease Control and PreventionJ. Michael Soucie - Emory UniversityJack E Edwards - Division of Infectious Diseases, Department of Internal Medicine, Harbor-UCLA Medical Center, University of California Los AngelesJan E Patterson - #N#6#N#Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas#N#Michael A Pfaller - University of IowaM. Sigfrido Rangel-Frausto - University of IowaMichael G Rinaldi - The University of Texas Health Science Center at San AntonioLisa Saiman - Columbia UniversityR. Todd Wiblin - University of IowaRichard P Wenzel - Virginia Commonwealth University Medical CenterNEMIS Prospective Multicenter Study Group
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.33(2), pp.177-186
- DOI
- 10.1086/321811
- PMID
- 11418877
- NLM abbreviation
- Clin Infect Dis
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Publisher
- The University of Chicago Press
- Language
- English
- Date published
- 07/15/2001
- Academic Unit
- Epidemiology; Pathology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984359785402771
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