Journal article
Risk Factors for Delirium in Patients Undergoing Hematopoietic Stem Cell Transplantation
Annals of clinical psychiatry, Vol.24(3), pp.204-214
08/2012
PMCID: PMC4120828
PMID: 22860240
Abstract
Background: Delirium is common after hematopoietic stem cell transplantation (HSCT) and is associated with increased morbidity and mortality. Early recognition and treatment have been shown to improve long-term outcomes. We sought to investigate the relationship between potential risk factors and the development of delirium following HSCT. Methods: Fifty-four inpatients admitted for HSCT were assessed prospectively for delirium every 2 to 3 days during their inpatient stay using standardized delirium and neuropsychological measures. Self reports of medical history, medical records, and neurocognitive and psychiatric assessments were used to identify risk factors. Both pre- and post-HSCT risk factors were examined. Results: Delirium incidence was 35% and occurred with highest frequency in the 2 weeks following transplant. The only pre-transplantation risk factor was lower oxygen saturation (P = .003). Post-transplantation risk factors for delirium included higher creatinine (P < .0001), higher blood urea nitrogen levels (P = .005), lower creatinine clearance (P = .0006), lower oxygen saturation (P = .001), lower hemoglobin (P = .04), and lower albumin (P = .03). There was no observed association with level of cognitive performance, transplant type, disease severity, medical comorbidity index, age, or conditioning regimen. Conclusions: Routine laboratory values can assist in the identification of high-risk patients before delirium onset to improve early detection and treatment of delirium after HSCT.
Details
- Title: Subtitle
- Risk Factors for Delirium in Patients Undergoing Hematopoietic Stem Cell Transplantation
- Creators
- Michelle T Weckmann - Department of Family Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USARoger Gingrich - Department of Internal Medicine, Division of Hematology, Oncology and Blood & Marrow Transplantation, University of Iowa Carver College of Medicine, Iowa City, IA, USAJames A Mills - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USALarry Hook - Department of Psychiatry, Medical College of Wisconsin, Milwaukee, WI, USALeigh J Beglinger - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Annals of clinical psychiatry, Vol.24(3), pp.204-214
- PMID
- 22860240
- PMCID
- PMC4120828
- ISSN
- 1040-1237
- eISSN
- 1547-3325
- Language
- English
- Date published
- 08/2012
- Academic Unit
- Psychiatry; Hematology, Oncology, and Blood & Marrow Transplantation; Family and Community Medicine; Internal Medicine
- Record Identifier
- 9984024412302771
Metrics
12 Record Views