Journal article
Risk factors and survival by HPV-16 E6 and E7 antibody status in human papillomavirus positive head and neck cancer
International journal of cancer, Vol.127(1), pp.111-117
2010
DOI: 10.1002/ijc.25015
PMID: 19876924
Abstract
High-risk human papillomavirus types (HPV-HR) are associated with head and neck cancer (HNC) risk and better survival. Most patients with HPV-HR DNA-positive tumors develop anti-HPV E6/E7 antibodies; however, it is unclear whether those who mount an immune response have similar risk factors or clinical outcomes as those who do not. HPV-16 DNA tumor-positive HNC cases were evaluated for HPV-16 E6 and E7 antibodies using a GST capture ELISA system. Among 57 HPV-16 DNA tumor-positive HNC cases, 67% were detected with HPV-16 E6 and/or E7 antibodies. Male gender (76% vs. 42%, p = 0.02), younger age (63% vs. 16%, p = 0.001) but not tobacco or alcohol were associated with E6 and/or E7 seropositivity. Seropositivity was associated more often with late stage (76%), poor grade (65%), positive nodes (82%). and in the oropharynx (82%), Median disease-specific and recurrence-free survival were longer in E6 and/or E7 seropositive compared to E6/E7-negative cases (2.2 years vs. 1.4 years, both outcomes), although results were not statistically significant. When examined jointly with p16 expression, E6 and/or E7-positive/p16-positive cases had better disease-specific (2.1 years vs. 1.1 years, p = 0.06) and recurrence-free (2.3 years vs. 1.1 years, p = 0.03) survival compared to E6-/E7-/p16- cases. These findings suggest there are 2 distinct HNC patient groups with HPV DNA-positive tumors, distinguishable by E6 and/or E7 antibody status. Differences in antibody status are associated with distinct risk factors and clinical outcomes. This information can be available as a simple blood test at initial presentation, before the removal of tissue through biopsy or surgery.
Details
- Title: Subtitle
- Risk factors and survival by HPV-16 E6 and E7 antibody status in human papillomavirus positive head and neck cancer
- Creators
- Elaine M SMITH - Department of Epidemiology, College of Public Health, University of lowa, lowa City, IA, United StatesMichael PAWLITA - Department of Genomic Modification and Carcinogenesis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, GermanyLinda M RUBENSTEIN - Department of Epidemiology, College of Public Health, University of lowa, lowa City, IA, United StatesThomas H HAUGEN - Veterans Affairs Medical Center and Department of Pathology, College of Medicine, University of lowa, lowa City, IA, United StatesEva HAMSIKOVA - Department of Experimental Virology, Institute of Hematology and Blood Transfusion, U nemocnice 1, Prague, Czech RepublicLubomir P TUREK - Veterans Affairs Medical Center and Department of Pathology, College of Medicine, University of lowa, lowa City, IA, United States
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.127(1), pp.111-117
- Publisher
- Wiley-Blackwell; Hoboken, NJ
- DOI
- 10.1002/ijc.25015
- PMID
- 19876924
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Language
- English
- Date published
- 2010
- Academic Unit
- Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9984046807602771
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