Risk factors associated with aortic and carotid intima-media thickness in adolescents and young adults: the Muscatine Offspring Study

Jeffrey D Dawson; Milan Sonka; Mary Beth Blecha; Wenjiao Lin; Patricia H Davis

doi:10.1016/j.jacc.2009.03.026

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Risk factors associated with aortic and carotid intima-media thickness in adolescents and young adults: the Muscatine Offspring Study

Journal article

Open access

Peer reviewed

Risk factors associated with aortic and carotid intima-media thickness in adolescents and young adults: the Muscatine Offspring Study

Jeffrey D Dawson, Milan Sonka, Mary Beth Blecha, Wenjiao Lin and Patricia H Davis

Journal of the American College of Cardiology, Vol.53(24), pp.2273-2279

06/16/2009

DOI: 10.1016/j.jacc.2009.03.026

PMCID: PMC2747309

PMID: 19520251

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Abstract

This study sought to determine whether cardiovascular risk factors are associated with aortic intima-media thickness (aIMT) and carotid intima-media thickness (cIMT) in adolescents and young adults. Atherosclerotic lesions begin developing in youth, first in the distal abdominal aorta and later in the carotid arteries. Knowledge of how risk factors relate to aIMT and cIMT may help in the design of early interventions to prevent cardiovascular disease. Participants were 635 members of the Muscatine Offspring cohort. The mean aIMT and cIMT were measured using an automated reading program. The mean (SD) values of aIMT and cIMT were 0.63 (0.14) and 0.49 (0.04) mm, respectively. In adolescents (age 11 to 17 years), aIMT was associated with triglycerides, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), and waist/hip ratio, after adjusting for age, sex, and height. In young adults (age 18 to 34 years), aIMT was associated with those same 5 risk factors, plus high-density lipoprotein cholesterol and pulse pressure. In adolescents, cIMT was associated with SBP, pulse pressure, heart rate, BMI, and waist/hip ratio. In young adults, cIMT was associated with total cholesterol, low-density lipoprotein cholesterol, triglycerides, SBP, DBP, BMI, waist/hip ratio, and glycosylated hemoglobin. In both age groups, aIMT and cIMT were significantly correlated with the Pathobiological Determinants of Atherosclerosis in Youth coronary artery risk score. Both aIMT and cIMT are associated with cardiovascular risk factors. Using aIMT in adolescents gives information beyond that obtained from cIMT alone. Measurement of aIMT and cIMT may help identify those at risk for premature cardiovascular disease.

Aortic Diseases - diagnostic imaging

Age Factors

Humans

Male

Young Adult

Aorta, Abdominal - diagnostic imaging

Carotid Artery Diseases - diagnostic imaging

Carotid Artery Diseases - pathology

Ultrasonography

Adult

Female

Tunica Intima - diagnostic imaging

Aorta, Abdominal - pathology

Child

Aortic Diseases - pathology

Adult Children

Arteriosclerosis - diagnostic imaging

Risk Factors

Carotid Arteries - diagnostic imaging

Tunica Intima - pathology

Adolescent

Carotid Artery Diseases - diagnosis

Carotid Arteries - pathology

Arteriosclerosis - pathology

Cohort Studies

Details

Title: Subtitle: Risk factors associated with aortic and carotid intima-media thickness in adolescents and young adults: the Muscatine Offspring Study
Creators: Jeffrey D Dawson - Department of Biostatistics, University of Iowa, Iowa City, IA 52242, USA. jeffreydawson@uiowa.edu
Milan Sonka
Mary Beth Blecha
Wenjiao Lin
Patricia H Davis
Resource Type: Journal article
Publication Details: Journal of the American College of Cardiology, Vol.53(24), pp.2273-2279
DOI: 10.1016/j.jacc.2009.03.026
PMID: 19520251
PMCID: PMC2747309
NLM abbreviation: J Am Coll Cardiol
ISSN: 0735-1097
eISSN: 1558-3597
Publisher: United States
Grant note: R01 HL054730-07 / NHLBI NIH HHS R01 HL054730-09 / NHLBI NIH HHS R01 HL054730-11 / NHLBI NIH HHS HL54730 / NHLBI NIH HHS R01 HL054730-06 / NHLBI NIH HHS R01 HL054730-08 / NHLBI NIH HHS R01 HL054730-05A1 / NHLBI NIH HHS R01 HL054730 / NHLBI NIH HHS R01 HL054730-12 / NHLBI NIH HHS UL1 RR024979 / NCRR NIH HHS R01 HL054730-10 / NHLBI NIH HHS
Language: English
Date published: 06/16/2009
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Public Health Administration; Electrical and Computer Engineering; Biostatistics; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9983997314102771

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