Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger

Mia M Gaudet; Michael F Press; Robert W Haile; Charles F Lynch; Sally L Glaser; Joellen Schildkraut; Marilie D Gammon; W Douglas Thompson; Jonine L Bernstein

doi:10.1007/s10549-011-1616-x

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Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger

Journal article

Peer reviewed

Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger

Mia M Gaudet, Michael F Press, Robert W Haile, Charles F Lynch, Sally L Glaser, Joellen Schildkraut, Marilie D Gammon, W Douglas Thompson and Jonine L Bernstein

Breast cancer research and treatment, Vol.130(2), pp.587-597

11/2011

DOI: 10.1007/s10549-011-1616-x

PMCID: PMC3721192

PMID: 21667121

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Abstract

Differences in incidence, prognosis, and treatment response suggest gene expression patterns may discern breast cancer subtypes with unique risk factor profiles; however, previous results were based predominantly on older women. In this study, we examined similar relationships in women ≤ 56 years, classified by immunohistochemical staining for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 for 890 breast cancer cases and 3,432 frequency-matched population-based controls. Odds ratios (OR) and 95% confidence intervals (CI) for tumor subtypes were calculated using multivariate polytomous regression models. A total of 455 (51.1%) tumors were considered luminal A, 72 (8.1%) luminal B, 117 (13.1%) non-luminal HER-2/neu+, and 246 (27.6%) triple negative. Triple negative tumors were associated with breast feeding duration (per 6 months: OR = 0.76, 95% CI 0.64-0.90). Among premenopausal women, increasing body size was more strongly associated with luminal B (OR = 1.73, 95% CI 1.07-2.77) and triple negative tumors (OR = 1.67, 95% CI 1.22-2.28). A history of benign breast disease was associated only with increased risk of luminal A tumors (OR = 1.89, 95% CI 1.43-2.50). A family history of breast cancer was a risk factor for luminal A tumors (OR = 1.93, 95% CI 1.38-2.70) regardless of age, and triple negative tumors with higher risks for women <45 (OR = 5.02, 95% CI 2.82-8.92; P for age interaction = 0.005). We found that little-to-no breastfeeding and high BMI were associated with increased risk of triple negative breast cancer. That some risk factors differ by molecular subtypes suggests etiologic heterogeneity in breast carcinogenesis among young women.

Breast Feeding

Body Mass Index

Multivariate Analysis

Receptors, Estrogen - metabolism

Carcinoma, Ductal, Breast - epidemiology

Humans

Middle Aged

Risk Factors

Receptor, ErbB-2 - metabolism

Case-Control Studies

Breast Neoplasms - metabolism

Receptors, Progesterone - metabolism

Young Adult

Adult

Female

Carcinoma, Ductal, Breast - metabolism

Breast Neoplasms - epidemiology

Details

Title: Subtitle: Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger
Creators: Mia M Gaudet - Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA. mia.gaudet@cancer.org
Michael F Press
Robert W Haile
Charles F Lynch
Sally L Glaser
Joellen Schildkraut
Marilie D Gammon
W Douglas Thompson
Jonine L Bernstein
Resource Type: Journal article
Publication Details: Breast cancer research and treatment, Vol.130(2), pp.587-597
DOI: 10.1007/s10549-011-1616-x
PMID: 21667121
PMCID: PMC3721192
NLM abbreviation: Breast Cancer Res Treat
ISSN: 1573-7217
eISSN: 1573-7217
Publisher: Netherlands
Grant note: 5R01CA064245 / NCI NIH HHS R01 CA064245-03 / NCI NIH HHS P30 ES010126 / NIEHS NIH HHS
Language: English
Date published: 11/2011
Academic Unit: Epidemiology
Record Identifier: 9983995112402771

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