Risk factors for and correlates of poststroke depression following discontinuation of antidepressants

Jess G FIEDOROWICZ; Kenji TAKEZAWA; Robert G ROBINSON

doi:10.1176/jnp.2007.19.4.399

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Risk factors for and correlates of poststroke depression following discontinuation of antidepressants

Journal article

Peer reviewed

Risk factors for and correlates of poststroke depression following discontinuation of antidepressants

Jess G FIEDOROWICZ, Kenji TAKEZAWA and Robert G ROBINSON

The journal of neuropsychiatry and clinical neurosciences, Vol.19(4), pp.399-405

2007

DOI: 10.1176/jnp.2007.19.4.399

PMID: 18070842

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Abstract

The authors randomly assigned nondepressed patients at least 3 months poststroke to receive nortriptyline, fluoxetine, or placebo for 3 months using double-blind methodology. Patients were followed at 3, 6, 9, and 21 months for new onset of depression. In patients treated with antidepressants, lesion volume and degree of social impairment were associated with subsequent late-onset of poststroke depression at 6 and 9 months. In the placebo group, severity of impairment in activities of daily living, at 3 and 9 months, was associated with late onset poststroke depression. Differences in the clinical/pathological correlates may reflect subtle differences in the pathophysiology of poststroke depression following prophylactic antidepressants.

Psychopharmacology

Neuropharmacology

Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer

Psychology. Psychoanalysis. Psychiatry

Adult and adolescent clinical studies

Pharmacology. Drug treatments

Psychopathology. Psychiatry

Mood disorders

Biological and medical sciences

Depression

Medical sciences

Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)

Details

Title: Subtitle: Risk factors for and correlates of poststroke depression following discontinuation of antidepressants
Creators: Jess G FIEDOROWICZ - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States
Kenji TAKEZAWA - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States
Robert G ROBINSON - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States
Resource Type: Journal article
Publication Details: The journal of neuropsychiatry and clinical neurosciences, Vol.19(4), pp.399-405
Publisher: American Psychiatric Press; Washington, DC
DOI: 10.1176/jnp.2007.19.4.399
PMID: 18070842
ISSN: 0895-0172
eISSN: 1545-7222
Language: English
Date published: 2007
Academic Unit: Psychiatry; Epidemiology; Iowa Neuroscience Institute
Record Identifier: 9984065479602771

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