Journal article
Risk factors for candidemia in Neonatal Intensive Care Unit patients
The Pediatric infectious disease journal, Vol.19(4), pp.319-324
04/2000
DOI: 10.1097/00006454-200004000-00011
PMID: 10783022
Abstract
BACKGROUND.Candida species are important nosocomial pathogens in neonatal intensive care unit (NICU) patients.\nMETHODS.\nRESULTS.In all, 2847 infants were enrolled and 35 (1.2%) developed candidemia (12.3 cases per 1000 patient discharges or 0.63 case per 1000 catheter days) including 23 of 421 (5.5%) babies ≤1000 g. After adjusting for birth weight and abdominal surgery, forward multivariate logistic regression analysis demonstrated significant risk factors, including gestational age <32 weeks, 5-min Apgar <5; shock, disseminated intravascular coagulopathy, prior use of intralipid, parenteral nutrition, central venous catheters, H2 blockers, intubation or length of stay >7 days before candidemia (P < 0.05). Catheters, steroids and GI tract colonization were not independent risk factors, but GI tract colonization preceded candidemia in 15 of 35 (43%) case patients.\nCONCLUSIONS.Candida spp. are an important cause of late onset sepsis in NICU patients. The incidence of candidemia might be decreased by the judicious use of treatments identified as risk factors and avoiding H2 blockers.
Details
- Title: Subtitle
- Risk factors for candidemia in Neonatal Intensive Care Unit patients
- Creators
- LISA SAIMAN - From the Department of Pediatrics, Columbia University, New York, NY (LS); the Departments of Biostatistics and Medicine, University of Iowa College of Medicine, Iowa City, IA (EL, MP, SRF, TW, JD); the Department of Medicine, Emory University School of Medicine and Grady Memorial Hospital (HMB), and the Hospital Infections Program, Centers for Disease Control and Prevention (WJ), Atlanta, GA; the Department of Medicine, University of Texas Health Science Center, San Antonio, TX (JEP, MR); the Department of Medicine, University of California School of Medicine, Los Angeles, CA (JEE); and the Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA (RPW)ELIZABETH LUDINGTONMICHAEL PFALLERSIGFRIDO RANGEL-FRAUSTOTODD WIBLINJEFFREY DAWSONHENRY BLUMBERGJAN PATTERSONMICHAEL RINALDIJACK EDWARDSRICHARD WENZELWILLIAM JARVISNational Epidemiology of Mycosis Survey Study Group
- Resource Type
- Journal article
- Publication Details
- The Pediatric infectious disease journal, Vol.19(4), pp.319-324
- DOI
- 10.1097/00006454-200004000-00011
- PMID
- 10783022
- NLM abbreviation
- Pediatr Infect Dis J
- ISSN
- 0891-3668
- eISSN
- 1532-0987
- Language
- English
- Date published
- 04/2000
- Academic Unit
- Public Health Administration; Epidemiology; Pathology; Biostatistics; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094662402771
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