Journal article
Risk factors for cardiovascular events and mortality in patients diagnosed with diffuse large B-cell lymphoma and treated with anthracyclines
Hematological oncology, Vol.40(4), pp.626-636
10/01/2022
DOI: 10.1002/hon.3034
PMID: 35644011
Abstract
There is an increased risk of congestive heart failure (CHF) following anthracycline-based chemotherapy in patients with Diffuse Large B-cell lymphoma (DLBCL). Little is known about risk factors of CHF, other cardiovascular events (CVE), and CVE effect on outcomes. We conducted a retrospective review of 463 newly diagnosed DLBCL patients treated between 2002 and 2016 with anthracycline containing regimens. At a median follow up of 71.3 months, 10.4% patients developed new CHF, 4.97% had new atrial fibrillation and 3.2% had new coronary artery disease. Age over 65, advanced stage DLBCL and diabetes were associated with increased cumulative incidence of CVE. Patients with prior diabetes had decreased progression-free survival and overall survival in comparison to non-diabetics. Patients who had a CVE in the first year had significant worse OS then patients who did not have a CVE (Hazard Ratio 10.0, 95% CI, 7.24-13.88). A risk score incorporating age at DLBCL diagnosis, baseline lymphocyte count, disease stage and diabetes stratified into groups with low, intermediate and high risk for CVE, with 1-year cumulative incidence of CVE of 5.3%, 7.9% and 13.4%. Diffuse large B-cell lymphoma patients treated with anthracycline containing regimens have high incidence of CVE, which are not limited to CHF. Clinical variables at the time of diagnosis can identify the group of DLBCL patients at highest risk of CVE, for whom preventive interventions should be considered.
Details
- Title: Subtitle
- Risk factors for cardiovascular events and mortality in patients diagnosed with diffuse large B-cell lymphoma and treated with anthracyclines
- Creators
- Akiva Diamond - Baylor College of MedicineSabarish Ayyappan - University of IowaShufen Cao - Case Western Reserve UniversityNour Tashtish - Case Western Reserve UniversityKirsten Boughan - Case Western Reserve UniversityBrenda Cooper - Case Western Reserve UniversityPingFu Fu - Case Western Reserve UniversityPaolo F. Caimi - Case Western Reserve University
- Resource Type
- Journal article
- Publication Details
- Hematological oncology, Vol.40(4), pp.626-636
- Publisher
- Wiley
- DOI
- 10.1002/hon.3034
- PMID
- 35644011
- ISSN
- 0278-0232
- eISSN
- 1099-1069
- Number of pages
- 11
- Language
- English
- Date published
- 10/01/2022
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359563302771
Metrics
12 Record Views