Risk factors for choroidal neovascularization and vision loss in the fellow eye study of CNVPT

Jonathan L Prenner; Brett J Rosenblatt; Michael J Tolentino; Gui-Shang Ying; Norren B Javornik; Maureen G Maguire; Allen C Ho; CNVPT Research Group

doi:10.1097/00006982-200306000-00004

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Risk factors for choroidal neovascularization and vision loss in the fellow eye study of CNVPT

Journal article

Peer reviewed

Risk factors for choroidal neovascularization and vision loss in the fellow eye study of CNVPT

Jonathan L Prenner, Brett J Rosenblatt, Michael J Tolentino, Gui-Shang Ying, Norren B Javornik, Maureen G Maguire, Allen C Ho and CNVPT Research Group

Retina (Philadelphia, Pa.), Vol.23(3), pp.307-314

06/2003

DOI: 10.1097/00006982-200306000-00004

PMID: 12824829

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Abstract

To identify risk factors for the development of choroidal neovascularization (CNV) and vision loss in the Fellow Eye Study of the Choroidal Neovascularization Prevention Trial. Retrospective review of 121 patients enrolled in a multicentered, randomized, controlled trial. Patients had neovascular age-related macular degeneration in one eye and more than 10 large drusen in the other eye. Records of patients randomly assigned to laser treatment or observation were reviewed through 4 years of follow-up. Three candidate risk factors for the development of CNV and vision loss were evaluated. Eyes with hyperfluorescent drusen on fluorescein angiography at 3 minutes appeared to have a decreased risk of CNV. Patchy choroidal filling was seen in 14% of patients. Eyes with patchy choroidal perfusion showed a higher risk of developing CNV that was not statistically significant, and the increased risk was present only in treated eyes. Reticular pseudodrusen were present in only three eyes. Reticular pseudodrusen were rare. Late drusen fluorescence may protect against the development of CNV.

Macular Degeneration - prevention & control

Follow-Up Studies

Humans

Macular Degeneration - complications

Middle Aged

Risk Factors

Choroidal Neovascularization - etiology

Male

Choroidal Neovascularization - prevention & control

Laser Coagulation

Visual Acuity

Blindness - prevention & control

Retinal Drusen - prevention & control

Aged, 80 and over

Female

Aged

Retinal Drusen - complications

Retrospective Studies

Blindness - etiology

Fluorescein Angiography

Details

Title: Subtitle: Risk factors for choroidal neovascularization and vision loss in the fellow eye study of CNVPT
Creators: Jonathan L Prenner - Associated Retinal Consultants, Royal Oak, Michigan, USA
Brett J Rosenblatt
Michael J Tolentino
Gui-Shang Ying
Norren B Javornik
Maureen G Maguire
Allen C Ho
CNVPT Research Group
Resource Type: Journal article
Publication Details: Retina (Philadelphia, Pa.), Vol.23(3), pp.307-314
Publisher: United States
DOI: 10.1097/00006982-200306000-00004
PMID: 12824829
ISSN: 0275-004X
eISSN: 1539-2864
Grant note: R21 EY11275 / NEI NIH HHS K08 EY13410 / NEI NIH HHS
Language: English
Date published: 06/2003
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983979919802771

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