Journal article
Risk factors for disease progression for adults and children with membranous nephropathy in the Cure Glomerulonephropathy Network (CureGN)
Kidney international reports, Vol.10(6), pp.1917-1928
06/2025
DOI: 10.1016/j.ekir.2025.03.027
PMCID: PMC12231017
PMID: 40630289
Abstract
Introduction
Primary membranous nephropathy (pMN) is a frequent cause of nephrotic syndrome in adult patients without diabetes. Recognizing the major shift in the classification of pMN based on target antigen and the management of patients with pMN with more widespread use of rituximab, we sought to better characterize the clinical course and risk factors in adults and children with pMN.
Methods
We used the Cure Glomerulonephropathy (CureGN) prospective cohort of pMN patients diagnosed by biopsy between 2010 and 2023. We report time to kidney outcomes using adjusted Cox proportional hazards models.
Results
In total, 591 patients (537 adults and 54 children) were evaluated with 9% reaching kidney failure. Anti-B cell therapy was used in 44% of patients. Age <18 years, self-reported Black/African American race, proteinuria >3 g/g and lower estimated glomerular filtration rate (eGFR) at enrollment were associated with worse kidney survival. Black race (adjusted hazard ratio, 1.8; 95% confidence interval, 1.1 to 2.9) and age <18 years (adjusted hazard ratio, 3.7; 95% confidence interval, 2.0 to 7.1) were associated with an increased risk of kidney failure and/or >40% eGFR decline after adjusting for exposure to immunosuppression. Latinx ethnicity was associated with a lower likelihood of reaching complete proteinuria remission (adjusted hazard ratio, 0.4; 95% confidence interval, 0.2 to 0.7).
Conclusion
This study unveils self-reported Black race, young age (<18 years) and Latinx ethnicity as potential risk factors associated with worse kidney outcomes.
Details
- Title: Subtitle
- Risk factors for disease progression for adults and children with membranous nephropathy in the Cure Glomerulonephropathy Network (CureGN)
- Creators
- Louis-Philippe LaurinMargaret HelmuthSalem AlmaaniIsabelle AyoubDhruti P. ChenLeonela A. VillegasCynthia C. NastBruce M. RobinsonVimal K. DerebailMeryl WaldmanAndrew S. BombackWooin AhnGerald AppelPaul AppelbaumRevekka BabayevPietro CanettaBrenda ChanVivette Denise D'AgatiSamitri DograHilda FernandezAli GharaviWilliam HinesSyed Ali HusainNamrata JainKrzysztof KirylukFangming LinMaddalena MarasaGlen MarkowitzHila Milo RasoulySumit MohanNicola MongeraJordan NestorThomas NickolasJai RadhakrishnanMaya RaoSimone Sanna-CherchiShayan ShirazianMichael Barry StokesNatalie UyAnthony ValeriNatalie VenaBartosz ForoncewiczBarbara MoszczukKrzysztof MuchaAgnieszka Perkowska-PtasińskaGian Marco GhiggeriFrancesca LuganiJosephine AmbruzsHelen LiapisRossana BaraccoAmrish JainIsa AshoorDiego AvilesTarak SrivastavaSun-Young AhnPrasad DevarajanElif ErkanDonna ClaesHillarey StoneSherene MasonRasheed GbadegesinLiliana Gomez-MendezLarry GreenbaumChia-shi WangHong (Julie) YinYi CaiGoebel JensJulia SteinkeDonald WeaverJerome LaneCarl CramerCindy PanNeil PaloianRajasree SreedharanDavid SelewskiKatherine TwombleyCorinna BowersMary DreherMahmoud KallashJohn MahanSamantha SharpeWilliam SmoyerAmira Al-UzriSandra IragorriMyda KhalidCraig BelshaJoseph AlgeMichael BraunA.C. GomezScott WenderferTetyana VasylyevaDaniel FeigGabriel Cara FuentesMelisha HannahCarla NesterAftab ChishtiJon KleinChryso KatsoufisWacharee Seeherunvong
- Resource Type
- Journal article
- Publication Details
- Kidney international reports, Vol.10(6), pp.1917-1928
- DOI
- 10.1016/j.ekir.2025.03.027
- PMID
- 40630289
- PMCID
- PMC12231017
- NLM abbreviation
- Kidney Int Rep
- ISSN
- 2468-0249
- eISSN
- 2468-0249
- Publisher
- ELSEVIER SCIENCE INC; NEW YORK
- Grant note
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NephCure Kidney International: 9/16/2013-5/31/2019
Funding for the CureGN consortium is provided by U24DK100845 (formerly UM1DK100845) , U01DK100846 (formerly UM1DK100846) , U01DK100876 (formerly UM1DK100876) , U01DK100866 (formerly UM1DK100866) , and U01DK100867 (formerly UM1DK100867) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) . Patient recruitment is supported by NephCure Kidney International.Dates of funding for first phase of CureGN was 9/16/2013-5/31/2019. LPL is a Fonds de recherche du Quebec-Sante Junior 2 Scholar.r National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) . Patient recruitment is supported by NephCure Kidney International. Dates of funding for first phase of CureGN was 9/16/2013-5/31/2019. LPL is a Fonds de recherche du Quebec-Sante Junior 2 Scholar.
- Language
- English
- Electronic publication date
- 03/2025
- Date published
- 06/2025
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984802502902771
Metrics
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