Journal article
Risk factors for immersion pulmonary edema: hyperoxia does not attenuate pulmonary hypertension associated with cold water-immersed prone exercise at 4.7 ATA
Journal of applied physiology (1985), Vol.110(3), pp.610-618
03/2011
DOI: 10.1152/japplphysiol.01088.2010
PMID: 21148341
Abstract
Hyperoxia has been shown to attenuate the increase in pulmonary artery (PA) pressure associated with immersed exercise in thermoneutral water, which could serve as a possible preventive strategy for the development of immersion pulmonary edema (IPE). We tested the hypothesis that the same is true during exercise in cold water. Six healthy volunteers instrumented with arterial and PA catheters were studied during two 16-min exercise trials during prone immersion in cold water (19.9–20.9°C) in normoxia [0.21 atmospheres absolute (ATA)] and hyperoxia (1.75 ATA) at 4.7 ATA. Heart rate (HR), Fick cardiac output (CO), mean arterial pressure (MAP), pulmonary artery pressure (PAP), pulmonary artery wedge pressure (PAWP), central venous pressure (CVP), arterial and venous blood gases, and ventilatory parameters were measured both early (E, 5–6 min) and late (L, 15–16 min) in exercise. During exercise at an average oxygen consumption rate (V̇o2) of 2.38 l/min, CO, CVP, and pulmonary vascular resistance were not affected by inspired (V̇o2) or exercise duration. Minute ventilation (V̇e), alveolar ventilation (V̇a), and ventilation frequency ( f) were significantly lower in hyperoxia compared with normoxia (mean ± SD: V̇e 58.8 ± 8.0 vs. 65.1 ± 9.2, P = 0.003; V̇a 40.2 ± 5.4 vs. 44.2 ± 9.0, P = 0.01; f 25.4 ± 5.4 vs. 27.2 ± 4.2, P = 0.04). Mixed venous pH was lower in hyperoxia compared with normoxia (7.17 ± 0.07 vs. 7.20 ± 0.07), and this result was significant early in exercise ( P = 0.002). There was no difference in mean PAP (MPAP: 28.28 ± 8.1 and 29.09 ± 14.3 mmHg) or PAWP (18.0 ± 7.6 and 18.7 ± 8.7 mmHg) between normoxia and hyperoxia, respectively. PAWP decreased from early to late exercise in hyperoxia ( P = 0.002). These results suggest that the increase in pulmonary vascular pressures associated with cold water immersion is not attenuated with hyperoxia.
Details
- Title: Subtitle
- Risk factors for immersion pulmonary edema: hyperoxia does not attenuate pulmonary hypertension associated with cold water-immersed prone exercise at 4.7 ATA
- Creators
- J. A. V Fraser - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North CarolinaD. F Peacher - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North CarolinaJ. J Freiberger - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North CarolinaM. J Natoli - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North CarolinaE. A Schinazi - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North CarolinaI. V Beck - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North CarolinaJ. R Walker - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North CarolinaP. O Doar - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North CarolinaA. E Boso - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North CarolinaA. J Walker - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North CarolinaD. N Kernagis - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North CarolinaR. E Moon - Center for Hyperbaric Medicine and Environmental Physiology and Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.110(3), pp.610-618
- DOI
- 10.1152/japplphysiol.01088.2010
- PMID
- 21148341
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 03/2011
- Academic Unit
- Anesthesia
- Record Identifier
- 9984006369502771
Metrics
16 Record Views