Journal article
Risk factors for infection with multidrug-resistant organisms in Haryana, India
American journal of infection control, Vol.46(3), pp.341-345
03/01/2018
DOI: 10.1016/j.ajic.2017.08.021
PMCID: PMC6055232
PMID: 29102426
Abstract
The objective of this study was to investigate risk factors for multidrug-resistant organism (MDRO) infection within patients from a tertiary care hospital in Northern India. This case-control study examined MDRO infection risk factors, including diet, health history, and medical device use. We administered a diet questionnaire to collect data on usual diet and collected data on other risk factors from chart review. All participants were inpatients identified through hospital microbiology reports. A total of 39 MDRO patient cases and 91 controls were included.
Descriptive statistics, univariate analysis, and multivariate logistic regression were performed to evaluate the association between risk factors and MDRO infection.
All cases had gram-negative MDRO infections. Univariate analyses found length of hospital stay, connective tissue disease, hospitalization in the last 12 months, hospitalization of a family member, in-hospital antibiotic use, antibiotic use in the last 12 months, and feeding tube, central venous line, and urinary catheter use to be significantly different between cases and controls. Logistic regression showed a >3-fold increase in the odds of infection with antibiotic use in the last 12 months (odds ratio [OR], 3.30; 95% confidence interval [CI], 1.22-8.91) and urinary catheter use (OR, 3.63; 95% CI, 1.14-11.58). Differences in dietary preferences and fruit, vegetable, and fiber consumption were not significantly associated with infection.
Antibiotic use is a major driver of MDRO infections. Our findings suggest that interventions optimizing antibiotic stewardship and reducing device use should be a priority to prevent MDRO infections.
Details
- Title: Subtitle
- Risk factors for infection with multidrug-resistant organisms in Haryana, India
- Creators
- Shilpa Kalluru - University of Wisconsin–MadisonShoshannah Eggers - William S. Middleton Memorial Veterans HospitalAnna Barker - University of Wisconsin–MadisonDaniel Shirley - University of Wisconsin–MadisonAjay K. Sethi - University of Wisconsin–MadisonSharmila Sengupta - Medanta Medicity Hospital, Gurgaon, Haryana, IndiaKajal Yeptho - Medanta Medicity Hospital, Gurgaon, Haryana, IndiaNasia Safdar - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- American journal of infection control, Vol.46(3), pp.341-345
- DOI
- 10.1016/j.ajic.2017.08.021
- PMID
- 29102426
- PMCID
- PMC6055232
- NLM abbreviation
- Am J Infect Control
- ISSN
- 0196-6553
- eISSN
- 1527-3296
- Publisher
- Elsevier Inc
- Grant note
- University of Wisconsin School of Medicine and Public Health (http://dx.doi.org/10.13039/100008028) Sherman & Gwendolyn Shapiro Foundation Farrell Scholars Indo-US Science and Technology Forum (http://dx.doi.org/10.13039/501100001429)
- Language
- English
- Date published
- 03/01/2018
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984446538602771
Metrics
11 Record Views