Journal article
Risk factors for isolated biliary atresia, National Birth Defects Prevention Study, 1997-2002
American Journal of Medical Genetics Part A, Vol.143A(19), pp.2274-2284
10/01/2007
DOI: 10.1002/ajmg.a.31926
PMID: 17726689
Abstract
Biliary atresia is a rare birth defect that affects 1 in 12,000 to 1 in 19,500 live births. We used data from the National Birth Defects Prevention Study, a multistate case-control study, to identify potential risk factors for isolated biliary atresia (no additional unrelated major birth defects diagnosed). Infants were identified from eight states from 1997 to 2002, with clinical information abstracted from medical records. Potential risk factors assessed include: demographic factors, seasonality, preterm birth, maternal smoking, maternal alcohol use, maternal illicit drug use, maternal health, maternal medication use, maternal vitamin use, and maternal nutrition. Infants of non-Hispanic black mothers were more likely to have biliary atresia than infants of non-Hispanic white mothers (adjusted odds ratio (aOR) = 2.29, 95% confidence interval (CI) 1.07–4.93) and infants conceived during the spring season were more likely to have biliary atresia than infants conceived in winter (aOR = 2.33, 95%CI 1.05–5.16). Low intakes of vitamin E, copper, phosphorus, and beta tocopherol were associated with the occurrence of isolated biliary atresia (borderline significance). Low iron intake had a borderline inverse association with biliary atresia. While this analysis provides support for previous reports of a possible association between seasonal variation and the occurrence of biliary atresia, more data are needed to evaluate whether the seasonal variation is related to infectious agents. The role of nutrients in the development of biliary atresia remains unclear. Further studies of genetic, infectious, and nutrient exposures and the association of biliary atresia are warranted.
Details
- Title: Subtitle
- Risk factors for isolated biliary atresia, National Birth Defects Prevention Study, 1997-2002
- Creators
- Natalie S The - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaMargaret A Honein - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaAlissa R Caton - Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Albany, New YorkCynthia A Moore - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaAnna Maria Siega-Riz - Departments of Epidemiology and Nutrition, School of Public Health, University of North Carolina, Chapel Hill, North CarolinaCharlotte M Druschel - Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Albany, New YorkNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- American Journal of Medical Genetics Part A, Vol.143A(19), pp.2274-2284
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/ajmg.a.31926
- PMID
- 17726689
- ISSN
- 1552-4825
- eISSN
- 1096-8628
- Number of pages
- 11
- Language
- English
- Date published
- 10/01/2007
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214680602771
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