Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study

Cindy M Chang; Sophia S Wang; Bhavana J Dave; Smrati Jain; Mohammad A Vasef; Dennis D Weisenburger; Wendy Cozen; Scott Davis; Richard K Severson; Charles F Lynch; Nathaniel Rothman; James R Cerhan; Patricia Hartge; Lindsay M Morton

doi:10.1002/ijc.25717

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Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study

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Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study

Cindy M Chang, Sophia S Wang, Bhavana J Dave, Smrati Jain, Mohammad A Vasef, Dennis D Weisenburger, Wendy Cozen, Scott Davis, Richard K Severson, Charles F Lynch, …

International journal of cancer, Vol.129(4), pp.938-947

08/15/2011

DOI: 10.1002/ijc.25717

PMCID: PMC3125462

PMID: 20949561

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Abstract

The t(14;18) chromosomal translocation is the most common cytogenetic abnormality in non-Hodgkin lymphoma (NHL), occurring in 70-90% of follicular lymphomas (FL) and 30-50% of diffuse large B-cell lymphomas (DLBCL). Previous t(14;18)-NHL studies have not evaluated risk factors for NHL defined by both t(14;18) status and histology. In this population-based case-control study, t(14;18) status was determined in DLBCL cases using fluorescence in situ hybridization on paraffin-embedded tumor sections. Polytomous logistic regression was used to evaluate the association between a wide variety of exposures and t(14;18)-positive (N=109) and -negative DLBCL (N=125) and FL (N=318), adjusting for sex, age, race, and study center. Taller height, more lifetime surgeries, and PCB180 exposure were associated with t(14;18)-positivity. Taller individuals (third tertile vs. first tertile) had elevated risks of t(14;18)-positive DLBCL (odds ratio [OR] = 1.8, 95% confidence interval [CI] 1.1-3.0) and FL (OR=1.4, 95%CI 1.0-1.9) but not t(14;18)-negative DLBCL. Similar patterns were seen for individuals with more lifetime surgeries (13+ vs. 0-12 surgeries; t(14;18)-positive DLBCL OR=1.4, 95%CI 0.7-2.7; FL OR=1.6, 95%CI 1.1-2.5) and individuals exposed to PCB180 greater than 20.8 ng/g (t(14;18)-positive DLBCL OR=1.3, 95%CI 0.6-2.9; FL OR=1.7, 95%CI 1.0-2.8). In contrast, termite treatment and high alpha-chlordane levels were associated with t(14;18)-negative DLBCL only, suggesting that these exposures do not act through t(14;18). Our findings suggest that putative associations between NHL and height, surgeries, and PCB180 may be t(14;18)-mediated and provide support for case-subtyping based on molecular and histologic subtypes. Future efforts should focus on pooling data to confirm and extend previous research on risk factors for t(14;18)-NHL subtypes.

Translocation, Genetic

United States - epidemiology

Prognosis

Lymphoma, Large B-Cell, Diffuse - pathology

Lymphoma, Follicular - pathology

Humans

Middle Aged

Risk Factors

In Situ Hybridization, Fluorescence

Male

Lymphoma, Follicular - classification

Case-Control Studies

Young Adult

Lymphoma, Follicular - epidemiology

Lymphoma, Follicular - genetics

Lymphoma, Large B-Cell, Diffuse - epidemiology

Lymphoma, Large B-Cell, Diffuse - classification

Adult

Female

Aged

Chromosomes, Human, Pair 18 - genetics

Lymphoma, Large B-Cell, Diffuse - genetics

Chromosomes, Human, Pair 14 - genetics

Details

Title: Subtitle: Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study
Creators: Cindy M Chang - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA. changcm@mail.nih.gov
Sophia S Wang
Bhavana J Dave
Smrati Jain
Mohammad A Vasef
Dennis D Weisenburger
Wendy Cozen
Scott Davis
Richard K Severson
Charles F Lynch
Nathaniel Rothman
James R Cerhan
Patricia Hartge
Lindsay M Morton
Resource Type: Journal article
Publication Details: International journal of cancer, Vol.129(4), pp.938-947
DOI: 10.1002/ijc.25717
PMID: 20949561
PMCID: PMC3125462
NLM abbreviation: Int J Cancer
ISSN: 0020-7136
eISSN: 1097-0215
Publisher: United States
Grant note: N01 PC067010 / NCI NIH HHS N02-PC-71105 / NCI NIH HHS N01-PC-67009 / NCI NIH HHS ZIA CP010176-10 / Intramural NIH HHS N01 PC067008 / NCI NIH HHS N01 PC065064 / NCI NIH HHS N01 PC067009 / NCI NIH HHS Z01 CP010170-07 / Intramural NIH HHS
Language: English
Date published: 08/15/2011
Academic Unit: Epidemiology
Record Identifier: 9983995025302771

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