Journal article
Risk factors for orofacial and limbtruncal tardive dyskinesia in older patients : a prospective longitudinal study
Psychopharmacologia, Vol.123(4), pp.307-314
1996
DOI: 10.1007/BF02246639
PMID: 8867868
Abstract
Although there is a consensus that orofacial and limbtruncal subtypes of tardive dyskinesia (TD) exist and may represent distinct pathophysiologic entities, few studies have examined the incidence of and risk factors associated with the development of these TD subtypes. Two hundred and sixty-six middle-aged and elderly outpatients with a median duration of 21 days of total lifetime neuroleptic exposure at study entry were evaluated at 1- to 3-month intervals. Using "mild" dyskinesia in any part of the body for diagnosis of TD, the cumulative incidence of orofacial TD was 38.5 and 65.7% after 1 and 2 years, respectively, whereas that of limbtruncal TD was 18.6 and 32.6% after 1 and 2 years. Preclinical dyskinesia was predictive of both orofacial and limbtruncal TD. History of alcohol abuse or dependence was a significant predictor of orofacial TD only whereas tremor was a significant predictor of limbtruncal TD only. Findings support suggestions that orofacial and limbtruncal TD may represent specific subsyndromes with different risk factors.
Details
- Title: Subtitle
- Risk factors for orofacial and limbtruncal tardive dyskinesia in older patients : a prospective longitudinal study
- Creators
- J. S PAULSEN - University of California at San Diego, 3350 La Jolla Village Drive, 9-116-B, San Diego, CA 92161, United StatesM. P CALIGIURI - University of California at San Diego, 3350 La Jolla Village Drive, 9-116-B, San Diego, CA 92161, United StatesB PALMER - University of California at San Diego, 3350 La Jolla Village Drive, 9-116-B, San Diego, CA 92161, United StatesL. A MCADAMS - University of California at San Diego, 3350 La Jolla Village Drive, 9-116-B, San Diego, CA 92161, United StatesD. V JESTE - University of California at San Diego, 3350 La Jolla Village Drive, 9-116-B, San Diego, CA 92161, United States
- Resource Type
- Journal article
- Publication Details
- Psychopharmacologia, Vol.123(4), pp.307-314
- Publisher
- Springer
- DOI
- 10.1007/BF02246639
- PMID
- 8867868
- ISSN
- 0033-3158
- eISSN
- 1432-2072
- Language
- English
- Date published
- 1996
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984083892302771
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