Risk factors for post-neonatal intensive care unit discharge mortality among extremely low birth weight infants

Lilia C De Jesus; Athina Pappas; Seetha Shankaran; Douglas Kendrick; Abhik Das; Rosemary D Higgins; Edward F Bell; Barbara J Stoll; Abbot R Laptook; Michele C Walsh; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

doi:10.1016/j.jpeds.2011.12.038

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Risk factors for post-neonatal intensive care unit discharge mortality among extremely low birth weight infants

Journal article

Open access

Peer reviewed

Risk factors for post-neonatal intensive care unit discharge mortality among extremely low birth weight infants

Lilia C De Jesus, Athina Pappas, Seetha Shankaran, Douglas Kendrick, Abhik Das, Rosemary D Higgins, Edward F Bell, Barbara J Stoll, Abbot R Laptook, Michele C Walsh, …

The Journal of pediatrics, Vol.161(1), pp.70-74.e2

07/2012

DOI: 10.1016/j.jpeds.2011.12.038

PMCID: PMC3366175

PMID: 22325187

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Abstract

The study goal was to evaluate maternal and neonatal risk factors associated with post-neonatal intensive care unit (NICU) discharge mortality among extremely low birth weight (ELBW) infants. This is a retrospective analysis of ELBW (<1000 g) and <27 weeks' gestational age infants born in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network sites between January 2000 and June 2007. Infants were tracked until death or 18 to 22 months' corrected age. Infants who died between NICU discharge and the 18- to 22-month follow-up visit were classified as post-NICU discharge mortality (P-NDM). Association of maternal and infant risk factors with P-NDM was determined using logistic regression analysis. A prediction model with 6 significant predictors was developed and validated. There were 5364 infants who survived to NICU discharge; 557 (10%) infants were lost to follow-up, and 107 infants died following NICU discharge. P-NDM rate was 22.3 per 1000 ELBW infants. In the prediction model, African American race, unknown maternal health insurance, and hospital stay ≥ 120 days significantly increased risk, and maternal exposure to intrapartum antibiotics was associated with decreased risk of P-NDM. We identified African American race, unknown medical insurance, and prolonged NICU stay as risk factors associated with P-NDM among ELBW infants.

Infant, Extremely Low Birth Weight

Infant Mortality

Intensive Care Units, Neonatal

Humans

Risk Factors

Patient Discharge

Female

Male

Retrospective Studies

Infant, Newborn

Cohort Studies

Details

Title: Subtitle: Risk factors for post-neonatal intensive care unit discharge mortality among extremely low birth weight infants
Creators: Lilia C De Jesus - Department of Pediatrics, Wayne State University, Detroit, MI, USA
Athina Pappas
Seetha Shankaran
Douglas Kendrick
Abhik Das
Rosemary D Higgins
Edward F Bell
Barbara J Stoll
Abbot R Laptook
Michele C Walsh
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.161(1), pp.70-74.e2
DOI: 10.1016/j.jpeds.2011.12.038
PMID: 22325187
PMCID: PMC3366175
NLM abbreviation: J Pediatr
ISSN: 0022-3476
eISSN: 1097-6833
Grant note: UG1 HD053089 / NICHD NIH HHS U10 HD27856 / NICHD NIH HHS M01 RR997 / NCRR NIH HHS UL1 TR000041 / NCATS NIH HHS M01 RR16587 / NCRR NIH HHS U10 HD53089 / NICHD NIH HHS U10 HD27880 / NICHD NIH HHS (U10 HD36790 / NICHD NIH HHS U10 HD27904 / NICHD NIH HHS M01 RR39 / NCRR NIH HHS U10 HD021385-26 / NICHD NIH HHS M01 RR32 / NCRR NIH HHS M01 RR7122 / NCRR NIH HHS U10 HD27853 / NICHD NIH HHS U10 HD053089 / NICHD NIH HHS M01 RR70 / NCRR NIH HHS NCRR UL1 024160 / PHS HHS M01 RR8084 / NCRR NIH HHS UL1 TR001449 / NCATS NIH HHS U10 HD40498 / NICHD NIH HHS UL1 TR000454 / NCATS NIH HHS M01 RR64 / NCRR NIH HHS M01 RR44 / NCRR NIH HHS UL1 RR24139 / NCRR NIH HHS U10 HD40492 / NICHD NIH HHS U10 HD021385 / NICHD NIH HHS U10 HD040461 / NICHD NIH HHS U10 HD53119 / NICHD NIH HHS M01 RR80 / NCRR NIH HHS M01 RR59 / NCRR NIH HHS U10 HD34216 / NICHD NIH HHS U10 HD27851 / NICHD NIH HHS M01 RR125 / NCRR NIH HHS U10 HD53109 / NICHD NIH HHS U10 HD21415 / NICHD NIH HHS U10 HD21364 / NICHD NIH HHS U10HD21397 / NICHD NIH HHS U10 HD27871 / NICHD NIH HHS U10 HD40689 / NICHD NIH HHS U10 HD21385 / NICHD NIH HHS U10 HD40461 / NICHD NIH HHS M01 RR633 / NCRR NIH HHS M01 RR750 / NCRR NIH HHS U10 HD40521 / NICHD NIH HHS M01 RR6022 / NCRR NIH HHS U10 HD21373 / NICHD NIH HHS U10 HD27881 / NICHD NIH HHS M01 RR30 / NCRR NIH HHS M01 RR54 / NCRR NIH HHS U10 HD53124 / NICHD NIH HHS
Language: English
Date published: 07/2012
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984093225602771

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