Risk factors for severity of juvenile-onset recurrent respiratory papillomatosis at first endoscopy

E Moreddu; E Lambert; D Kacmarynski; R Nicollas; J.-M Triglia; R.J Smith

doi:10.1016/j.anorl.2018.11.007

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Risk factors for severity of juvenile-onset recurrent respiratory papillomatosis at first endoscopy

Journal article

Open access

Peer reviewed

Risk factors for severity of juvenile-onset recurrent respiratory papillomatosis at first endoscopy

E Moreddu, E Lambert, D Kacmarynski, R Nicollas, J.-M Triglia and R.J Smith

European annals of otorhinolaryngology, head and neck diseases, Vol.136(1), pp.25-28

02/2019

DOI: 10.1016/j.anorl.2018.11.007

PMID: 30503689

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Abstract

The study objective was to determine risk factors for severity of juvenile-onset recurrent respiratory papillomatosis (RRP) at first endoscopic evaluation. Based on a review of all cases undergoing surgery for juvenile-onset RRP in two pediatric otolaryngology departments in the USA and France, the following severity risk factors were analyzed: number of laryngeal levels involved, extension to the subglottis, and bilateral involvement. Thirty-two patients were included, with 571 endoscopic procedures. Number of endoscopies per patient varied according to initial extension: 30.67 procedures when all three levels were involved, 15.57 procedures when two and 14.08 procedures when only one (P=0.03). The odds ratio for risk of >14 procedures in 3-level involvement was 20.43 (P=0.047). Initial subglottic extension tended to be associated with more endoscopic procedures (23.67 vs 15.56, P=0.16). RRP severity correlated with initial laryngeal extension of papillomatous lesions at first endoscopy. This finding allowed a short 3-item assessment scale to be created for routine use, complementary to Derkay's assessment scale.

Juvenile-onset papillomatosis

Human papillomavirus

Larynx

Cidofovir

Children

Details

Title: Subtitle: Risk factors for severity of juvenile-onset recurrent respiratory papillomatosis at first endoscopy
Creators: E Moreddu - Service d’ORL pédiatrique et chirurgie cervico-faciale, hôpital d’Enfants de La Timone, Aix-Marseille université, 13385 Marseille, France
E Lambert - Department of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
D Kacmarynski - Department of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
R Nicollas - Service d’ORL pédiatrique et chirurgie cervico-faciale, hôpital d’Enfants de La Timone, Aix-Marseille université, 13385 Marseille, France
J.-M Triglia - Service d’ORL pédiatrique et chirurgie cervico-faciale, hôpital d’Enfants de La Timone, Aix-Marseille université, 13385 Marseille, France
R.J Smith - Department of Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: European annals of otorhinolaryngology, head and neck diseases, Vol.136(1), pp.25-28
DOI: 10.1016/j.anorl.2018.11.007
PMID: 30503689
NLM abbreviation: Eur Ann Otorhinolaryngol Head Neck Dis
ISSN: 1879-7296
eISSN: 1879-730X
Publisher: Elsevier Masson SAS
Language: English
Date published: 02/2019
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center; Otolaryngology; Internal Medicine
Record Identifier: 9984006492302771

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